P63 and P73: Teammates or adversaries?

Edward Ratovitski; Barry Trink; David Sidransky

doi:10.1016/j.ccr.2005.12.027

P63 and P73: Teammates or adversaries?

Edward Ratovitski, Barry Trink, David Sidransky

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

13 Scopus citations

Abstract

The status and interrelationship of p53 family members are critical elements in tumor progression. An intriguing paper in this issue of Cancer Cell (Rocco et al., 2006) reveals a new twist in the interactions between p63 and p73 following DNA damage, underscoring a role for p73 in the proapoptotic regulation of Puma, Noxa, and Bcl-2 in head and neck squamous cell carcinomas (HNSCC). These data define a pathway in which ΔNp63α promotes survival in squamous epithelial malignancy by repressing a p73-dependent proapoptotic transcriptional program, suggesting that p63 levels and p73 status may be key determinants of tumor response in patients with HNSCC.

Original language	English (US)
Pages (from-to)	1-2
Number of pages	2
Journal	Cancer cell
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/j.ccr.2005.12.027
State	Published - Jan 2006

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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10.1016/j.ccr.2005.12.027

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title = "P63 and P73: Teammates or adversaries?",

abstract = "The status and interrelationship of p53 family members are critical elements in tumor progression. An intriguing paper in this issue of Cancer Cell (Rocco et al., 2006) reveals a new twist in the interactions between p63 and p73 following DNA damage, underscoring a role for p73 in the proapoptotic regulation of Puma, Noxa, and Bcl-2 in head and neck squamous cell carcinomas (HNSCC). These data define a pathway in which ΔNp63α promotes survival in squamous epithelial malignancy by repressing a p73-dependent proapoptotic transcriptional program, suggesting that p63 levels and p73 status may be key determinants of tumor response in patients with HNSCC.",

author = "Edward Ratovitski and Barry Trink and David Sidransky",

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AU - Trink, Barry

AU - Sidransky, David

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AB - The status and interrelationship of p53 family members are critical elements in tumor progression. An intriguing paper in this issue of Cancer Cell (Rocco et al., 2006) reveals a new twist in the interactions between p63 and p73 following DNA damage, underscoring a role for p73 in the proapoptotic regulation of Puma, Noxa, and Bcl-2 in head and neck squamous cell carcinomas (HNSCC). These data define a pathway in which ΔNp63α promotes survival in squamous epithelial malignancy by repressing a p73-dependent proapoptotic transcriptional program, suggesting that p63 levels and p73 status may be key determinants of tumor response in patients with HNSCC.

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P63 and P73: Teammates or adversaries?

Abstract

ASJC Scopus subject areas

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