P63 and P73: Teammates or adversaries?

Edward Ratovitski, Barry Trink, David Sidransky

Research output: Contribution to journalShort surveypeer-review

Abstract

The status and interrelationship of p53 family members are critical elements in tumor progression. An intriguing paper in this issue of Cancer Cell (Rocco et al., 2006) reveals a new twist in the interactions between p63 and p73 following DNA damage, underscoring a role for p73 in the proapoptotic regulation of Puma, Noxa, and Bcl-2 in head and neck squamous cell carcinomas (HNSCC). These data define a pathway in which ΔNp63α promotes survival in squamous epithelial malignancy by repressing a p73-dependent proapoptotic transcriptional program, suggesting that p63 levels and p73 status may be key determinants of tumor response in patients with HNSCC.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalCancer cell
Volume9
Issue number1
DOIs
StatePublished - Jan 2006

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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