P53 Tumor suppression network in cancer Epigenetics

Alok Mishra; Daniel J. Brat; Mukesh Verma

doi:10.1007/978-1-4939-1804-1_31

P53 Tumor suppression network in cancer Epigenetics

Alok Mishra, Daniel J. Brat, Mukesh Verma

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The tumor suppressor p53 is one of the most complex and widely studied genes in cancer biology. In spite of the vast on literature the transcriptional regulation of p53, aspects of its especially epigenetic regulation are not completely understood. This chapter presents a concise overview of p53-related epigenetic events involved in oncogenesis and tumor suppression. We limit the scope to epigenetic modifications of the p53 promoter per se as well as its well-established downstream targets. The indirect role of p53 affecting the epigenetic machinery of cancer cells via specific proteins and transcription factors is discussed. Current concepts of p53-related cancer epigenetics offer myriad avenues for cancer therapies. Challenges in the field are also discussed.

Original language	English (US)
Pages (from-to)	597-605
Number of pages	9
Journal	Methods in Molecular Biology
Volume	1238
DOIs	https://doi.org/10.1007/978-1-4939-1804-1_31
State	Published - 2015
Externally published	Yes

Keywords

Acetylation
Cancer
ChIP
Chromatin
Epigenetic
Histones
Methylation
Micro RNA
P53

ASJC Scopus subject areas

Molecular Biology
Genetics

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10.1007/978-1-4939-1804-1_31

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title = "P53 Tumor suppression network in cancer Epigenetics",

abstract = "The tumor suppressor p53 is one of the most complex and widely studied genes in cancer biology. In spite of the vast on literature the transcriptional regulation of p53, aspects of its especially epigenetic regulation are not completely understood. This chapter presents a concise overview of p53-related epigenetic events involved in oncogenesis and tumor suppression. We limit the scope to epigenetic modifications of the p53 promoter per se as well as its well-established downstream targets. The indirect role of p53 affecting the epigenetic machinery of cancer cells via specific proteins and transcription factors is discussed. Current concepts of p53-related cancer epigenetics offer myriad avenues for cancer therapies. Challenges in the field are also discussed.",

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AU - Mishra, Alok

AU - Brat, Daniel J.

AU - Verma, Mukesh

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PY - 2015

Y1 - 2015

N2 - The tumor suppressor p53 is one of the most complex and widely studied genes in cancer biology. In spite of the vast on literature the transcriptional regulation of p53, aspects of its especially epigenetic regulation are not completely understood. This chapter presents a concise overview of p53-related epigenetic events involved in oncogenesis and tumor suppression. We limit the scope to epigenetic modifications of the p53 promoter per se as well as its well-established downstream targets. The indirect role of p53 affecting the epigenetic machinery of cancer cells via specific proteins and transcription factors is discussed. Current concepts of p53-related cancer epigenetics offer myriad avenues for cancer therapies. Challenges in the field are also discussed.

AB - The tumor suppressor p53 is one of the most complex and widely studied genes in cancer biology. In spite of the vast on literature the transcriptional regulation of p53, aspects of its especially epigenetic regulation are not completely understood. This chapter presents a concise overview of p53-related epigenetic events involved in oncogenesis and tumor suppression. We limit the scope to epigenetic modifications of the p53 promoter per se as well as its well-established downstream targets. The indirect role of p53 affecting the epigenetic machinery of cancer cells via specific proteins and transcription factors is discussed. Current concepts of p53-related cancer epigenetics offer myriad avenues for cancer therapies. Challenges in the field are also discussed.

KW - Acetylation

KW - Cancer

KW - ChIP

KW - Chromatin

KW - Epigenetic

KW - Histones

KW - Methylation

KW - Micro RNA

KW - P53

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P53 Tumor suppression network in cancer Epigenetics

Abstract

Keywords

ASJC Scopus subject areas

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