Abstract
The p53 tumor suppressor gene plays an instrumental role in transcriptional regulation of target genes involved in cellular stress responses. p53-dependent transactivation and transrepression require its interaction with p300/CBP, a coactivator that also interacts with the ReIA subunit of nuclear factor-κB. We find that p53 inhibits RelA-dependent transactivation without altering ReIA expression or inducible κB-DNA binding. p53-mediated repression of RelA is relieved by p300 overexpression and the increased RelA activity conferred by p53-deficiency is counteracted by either transactivation domain-deficient p300 fragments that bind RelA or a transdominant mutant of IκBα. Our results suggest that p53 can regulate diverse κB-dependent cellular responses.
Original language | English (US) |
---|---|
Pages (from-to) | 4531-4536 |
Number of pages | 6 |
Journal | Cancer Research |
Volume | 58 |
Issue number | 20 |
State | Published - Oct 15 1998 |
ASJC Scopus subject areas
- Oncology
- Cancer Research