p53, Mdm2, and c-Myc overexpression is associated with a poor prognosis in aggressive non-Hodgkin's lymphomas

Susanne Widell, Robert Hast, Christopher Cox, Gert Auer, John M. Bennett

Research output: Contribution to journalArticlepeer-review

Abstract

The expression of p53, p21/WAF-1, Mdm2, c-Myc, and proliferating cell nuclear antigen (PCNA) proteins was examined by the immunohistochemistry of paraffin-embedded tissues of 62 patients with aggressive non-Hodgkin's lymphomas (NHL) and correlated to clinical data. Expression of p53, p21/WAF-1, Mdm2, and c-Myc protein was observed in 17 out of 62 cases (30%), 25 out of 60 (42%), 13 out of 44 (30%), and 39 out of 51 (76.5%), respectively. The p53+/p21WAF-1 phenotype, which is more frequently found in p53 mutations, was associated with a worse overall survival (P = 0.04) and with a lower rate of complete response (CR) (PF = 0.01). p53 and c-Myc negative expression was related to a better response to chemotherapy (PF = 0.005 and 0.035, respectively). The expression of p53, c-Myc, and Mdm2 was related to a shortened overall survival (P < 0.001, 0.05, and 0.037, respectively), suggesting that the expression of these proteins could be associated with a poor outcome in these patients.

Original languageEnglish (US)
Pages (from-to)84-92
Number of pages9
JournalAmerican journal of hematology
Volume67
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Mdm2
  • Non-Hodgkin's lymphoma
  • Prognosis
  • c-Myc
  • p21/WAF-1
  • p53

ASJC Scopus subject areas

  • Hematology

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