p53 functions as a cell cycle control protein in osteosarcomas

Lisa Diller, Jayne Kassel, Camille E. Nelson, Magdalena A. Gryka, Gregory Litwak, Mark Gebhardt, Brigitte Bressac, Mehmet Ozturk, Suzanne J. Baker, Bert Vogelstein, Stephen H. Friend

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Abstract

Mutations in the p53 gene have been associated with a wide range of human tumors, including osteosarcomas. Although it has been shown that wild-type p53 can block the ability of E1a and ras to cotransform primary rodent cells, it is poorly understood why inactivation of the p53 gene is important for tumor formation. We show that overexpression of the gene encoding wild-type p53 blocks the growth of osteosarcoma cells. The growth arrest was determined to be due to an inability of the transfected cells to progress into S phase. This suggests that the role of the p53 gene as an antioncogene may be in controlling the cell cycle in a fashion analogous to the check-point control genes in Saccharomyces cerevisiae.

Original languageEnglish (US)
Pages (from-to)5772-5781
Number of pages10
JournalMolecular and cellular biology
Volume10
Issue number11
DOIs
StatePublished - Jan 1 1990

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Diller, L., Kassel, J., Nelson, C. E., Gryka, M. A., Litwak, G., Gebhardt, M., Bressac, B., Ozturk, M., Baker, S. J., Vogelstein, B., & Friend, S. H. (1990). p53 functions as a cell cycle control protein in osteosarcomas. Molecular and cellular biology, 10(11), 5772-5781. https://doi.org/10.1128/MCB.10.11.5772