P53 as guardian of the mitochondrial genome

Ji Hoon Park, Jie Zhuang, Jie Li, Paul M. Hwang, Wilhelm Just

Research output: Contribution to journalArticlepeer-review

Abstract

Participating in the repair of nuclear DNA is one mechanism by which p53 suppresses tumorigenesis, but there is growing evidence that p53 also helps maintain the mitochondrial genome through its translocation into mitochondria and interactions with mtDNA repair proteins. Because of the susceptibility of mtDNA to oxidative damage and replication errors, it is vital to protect mtDNA genomic stability to preserve health and fitness. Here, we focus on reviewing the evidence for the involvement of p53 in maintaining the integrity of mtDNA through its activities in both the nucleus and the mitochondria.

Original languageEnglish (US)
Pages (from-to)924-934
Number of pages11
JournalFEBS Letters
Volume590
Issue number7
DOIs
StatePublished - Apr 1 2016

Keywords

  • DNA repair
  • mitochondria
  • mtDNA
  • p53
  • reactive oxygen species
  • translocation

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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