p53 and CD44 as clinical markers of tumour progression in colorectal carcinogenesis

J. W R Mulder; V. J M Wielenga; S. T. Pals; G. J A Offerhaus

doi:10.1023/A:1026403404652

p53 and CD44 as clinical markers of tumour progression in colorectal carcinogenesis

J. W R Mulder, V. J M Wielenga, S. T. Pals, G. J A Offerhaus

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Recent advances in molecular genetics have importantly improved our understanding of the development of colorectal cancer. The present review gives an overview of the clinical value of the tumour-suppressor gene, p53, and the CD44 cell adhesion molecule in colorectal cancer and the pitfalls encountered in the immunohistochemical detection of these proteins. Immunohistochemistry potentially forms a procedure applicable for routine diagnosis and prognostication. Therefore, p53 expression and the independent prognostic importance of CD44v6 expression is given particular emphasis, and other molecular events underlying colorectal carcinogenesis are only mentioned briefly.

Original language	English (US)
Pages (from-to)	439-452
Number of pages	14
Journal	The Histochemical Journal
Volume	29
Issue number	6
DOIs	https://doi.org/10.1023/A:1026403404652
State	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

Anatomy
Cell Biology

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abstract = "Recent advances in molecular genetics have importantly improved our understanding of the development of colorectal cancer. The present review gives an overview of the clinical value of the tumour-suppressor gene, p53, and the CD44 cell adhesion molecule in colorectal cancer and the pitfalls encountered in the immunohistochemical detection of these proteins. Immunohistochemistry potentially forms a procedure applicable for routine diagnosis and prognostication. Therefore, p53 expression and the independent prognostic importance of CD44v6 expression is given particular emphasis, and other molecular events underlying colorectal carcinogenesis are only mentioned briefly.",

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AU - Wielenga, V. J M

AU - Pals, S. T.

AU - Offerhaus, G. J A

PY - 1997

Y1 - 1997

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AB - Recent advances in molecular genetics have importantly improved our understanding of the development of colorectal cancer. The present review gives an overview of the clinical value of the tumour-suppressor gene, p53, and the CD44 cell adhesion molecule in colorectal cancer and the pitfalls encountered in the immunohistochemical detection of these proteins. Immunohistochemistry potentially forms a procedure applicable for routine diagnosis and prognostication. Therefore, p53 expression and the independent prognostic importance of CD44v6 expression is given particular emphasis, and other molecular events underlying colorectal carcinogenesis are only mentioned briefly.

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p53 and CD44 as clinical markers of tumour progression in colorectal carcinogenesis

Abstract

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