p38 MAP kinase activity modulates αβ T cell development

Thomas Mulroy, Jyoti Sen

Research output: Contribution to journalArticlepeer-review

Abstract

Reciprocal interactions between bone marrow derived precursor cells and the thymic environment lead to the generation of the complete repertoire of diverse and functional T cells. We have previously shown that p38 MAP kinase is activated in response to intrathymic signals in thymocytes. In this report we provide evidence that p38 MAP kinase activity is essential for pre-TCR-mediated transition of thymocytes from the CD4- CD8- to the CD4+ CD8+ stage of development. In the absence of p38 MAP kinase activity differentiation of αβ T cells, but not γδ T cells, was blocked.

Original languageEnglish (US)
Pages (from-to)3056-3063
Number of pages8
JournalEuropean Journal of Immunology
Volume31
Issue number10
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • p38 MAP kinase
  • Pre-T cell receptor
  • Signal transduction
  • Thymus

ASJC Scopus subject areas

  • Immunology

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