p21(Waf1/Cip1) expression and the p53/MDM2 feedback loop in gastric carcinogenesis

M. E. Craanen, P. Blok, G. J A Offerhaus, G. A. Meijer, W. Dekker, E. J. Kuipers, S. G M Meuwissen

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Data are non-existent regarding coincidental alterations in the expression of p53 and its downstream target genes MDM2 and p21(Waf1/Cip1) in gastric carcinogenesis. An immunohistochemical study was therefore performed to examine the interrelationships of p53, MDM2, and p21(Waf1/Cip1) expression in a series of Caucasian early gastric carcinomas and precursor lesions. In normal gastric mucosa, chronic gastritis, and intestinal metaplasia, the surface cells expressed p21(Waf1/Cip1) in the absence of detectable nuclear p53 and MDM2 protein. Nuclear p53 protein accumulation was found in 60 per cent of the carcinomas, with significant differences in staining characteristics between the Lauren types in the absence of detectable MDM2 protein (p

Original languageEnglish (US)
Pages (from-to)481-486
Number of pages6
JournalJournal of Pathology
Issue number4
StatePublished - 1999
Externally publishedYes


  • Cell cycle
  • Early gastric carcinoma
  • Gastric carcinogenesis
  • Immunohistochemistry
  • MDM2 oncogene
  • P21(Waf1/Cip1) gene
  • P53 tumour suppressor gene
  • Stomach

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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