p21(Waf1/Cip1) expression and the p53/MDM2 feedback loop in gastric carcinogenesis

M. E. Craanen; P. Blok; G. J A Offerhaus; G. A. Meijer; W. Dekker; E. J. Kuipers; S. G M Meuwissen

doi:10.1002/(SICI)1096-9896(199912)189:4<481::AID-PATH482>3.0.CO;2-U

p21(Waf1/Cip1) expression and the p53/MDM2 feedback loop in gastric carcinogenesis

M. E. Craanen, P. Blok, G. J A Offerhaus, G. A. Meijer, W. Dekker, E. J. Kuipers, S. G M Meuwissen

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Data are non-existent regarding coincidental alterations in the expression of p53 and its downstream target genes MDM2 and p21(Waf1/Cip1) in gastric carcinogenesis. An immunohistochemical study was therefore performed to examine the interrelationships of p53, MDM2, and p21(Waf1/Cip1) expression in a series of Caucasian early gastric carcinomas and precursor lesions. In normal gastric mucosa, chronic gastritis, and intestinal metaplasia, the surface cells expressed p21(Waf1/Cip1) in the absence of detectable nuclear p53 and MDM2 protein. Nuclear p53 protein accumulation was found in 60 per cent of the carcinomas, with significant differences in staining characteristics between the Lauren types in the absence of detectable MDM2 protein (p

Original language	English (US)
Pages (from-to)	481-486
Number of pages	6
Journal	Journal of Pathology
Volume	189
Issue number	4
DOIs	https://doi.org/10.1002/(SICI)1096-9896(199912)189:4<481::AID-PATH482>3.0.CO;2-U
State	Published - 1999
Externally published	Yes

Keywords

Cell cycle
Early gastric carcinoma
Gastric carcinogenesis
Immunohistochemistry
MDM2 oncogene
P21(Waf1/Cip1) gene
P53 tumour suppressor gene
Stomach

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1002/(SICI)1096-9896(199912)189:4<481::AID-PATH482>3.0.CO;2-U

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title = "p21(Waf1/Cip1) expression and the p53/MDM2 feedback loop in gastric carcinogenesis",

abstract = "Data are non-existent regarding coincidental alterations in the expression of p53 and its downstream target genes MDM2 and p21(Waf1/Cip1) in gastric carcinogenesis. An immunohistochemical study was therefore performed to examine the interrelationships of p53, MDM2, and p21(Waf1/Cip1) expression in a series of Caucasian early gastric carcinomas and precursor lesions. In normal gastric mucosa, chronic gastritis, and intestinal metaplasia, the surface cells expressed p21(Waf1/Cip1) in the absence of detectable nuclear p53 and MDM2 protein. Nuclear p53 protein accumulation was found in 60 per cent of the carcinomas, with significant differences in staining characteristics between the Lauren types in the absence of detectable MDM2 protein (p",

keywords = "Cell cycle, Early gastric carcinoma, Gastric carcinogenesis, Immunohistochemistry, MDM2 oncogene, P21(Waf1/Cip1) gene, P53 tumour suppressor gene, Stomach",

author = "Craanen, {M. E.} and P. Blok and Offerhaus, {G. J A} and Meijer, {G. A.} and W. Dekker and Kuipers, {E. J.} and Meuwissen, {S. G M}",

year = "1999",

doi = "10.1002/(SICI)1096-9896(199912)189:4<481::AID-PATH482>3.0.CO;2-U",

language = "English (US)",

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AU - Craanen, M. E.

AU - Blok, P.

AU - Offerhaus, G. J A

AU - Meijer, G. A.

AU - Dekker, W.

AU - Kuipers, E. J.

AU - Meuwissen, S. G M

PY - 1999

Y1 - 1999

N2 - Data are non-existent regarding coincidental alterations in the expression of p53 and its downstream target genes MDM2 and p21(Waf1/Cip1) in gastric carcinogenesis. An immunohistochemical study was therefore performed to examine the interrelationships of p53, MDM2, and p21(Waf1/Cip1) expression in a series of Caucasian early gastric carcinomas and precursor lesions. In normal gastric mucosa, chronic gastritis, and intestinal metaplasia, the surface cells expressed p21(Waf1/Cip1) in the absence of detectable nuclear p53 and MDM2 protein. Nuclear p53 protein accumulation was found in 60 per cent of the carcinomas, with significant differences in staining characteristics between the Lauren types in the absence of detectable MDM2 protein (p

AB - Data are non-existent regarding coincidental alterations in the expression of p53 and its downstream target genes MDM2 and p21(Waf1/Cip1) in gastric carcinogenesis. An immunohistochemical study was therefore performed to examine the interrelationships of p53, MDM2, and p21(Waf1/Cip1) expression in a series of Caucasian early gastric carcinomas and precursor lesions. In normal gastric mucosa, chronic gastritis, and intestinal metaplasia, the surface cells expressed p21(Waf1/Cip1) in the absence of detectable nuclear p53 and MDM2 protein. Nuclear p53 protein accumulation was found in 60 per cent of the carcinomas, with significant differences in staining characteristics between the Lauren types in the absence of detectable MDM2 protein (p

KW - Cell cycle

KW - Early gastric carcinoma

KW - Gastric carcinogenesis

KW - Immunohistochemistry

KW - MDM2 oncogene

KW - P21(Waf1/Cip1) gene

KW - P53 tumour suppressor gene

KW - Stomach

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ER -

p21(Waf1/Cip1) expression and the p53/MDM2 feedback loop in gastric carcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

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