Abstract
Cu-transporting ATPases or Cu pumps are essential for normal homeostasis of all living organisms. Their activity is required for microbial pathogenicity, pheromone sensing by plants, neuronal activity in mammals, and many other physiological processes. Cu pumps transport copper from the cytosol across membranes to maintain copper balance and deliver copper cofactor to cuproenzymes. Genetic mutations in human Cu pumps result in severe disorders, Menkes disease, and Wilson's disease. This article describes the biological roles of Cu pumps, discusses the structure and mechanism of Cu pumps in comparison to other P-type ATPases, and summarizes the current data on Cu pump regulation.
| Original language | English (US) |
|---|---|
| Title of host publication | Encyclopedia of Biological Chemistry |
| Subtitle of host publication | Second Edition |
| Publisher | Elsevier Inc. |
| Pages | 670-675 |
| Number of pages | 6 |
| ISBN (Electronic) | 9780123786319 |
| ISBN (Print) | 9780123786302 |
| DOIs | |
| State | Published - Feb 15 2013 |
Keywords
- Atox1
- ATP7A
- ATP7B
- CopA
- Copper
- Copper chaperone
- CxxC
- Menkes Disease
- P-type ATPase
- Wilson's disease
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology