P-Type Pumps: Copper Pump

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cu-transporting ATPases or Cu pumps are essential for normal homeostasis of all living organisms. Their activity is required for microbial pathogenicity, pheromone sensing by plants, neuronal activity in mammals, and many other physiological processes. Cu pumps transport copper from the cytosol across membranes to maintain copper balance and deliver copper cofactor to cuproenzymes. Genetic mutations in human Cu pumps result in severe disorders, Menkes disease, and Wilson's disease. This article describes the biological roles of Cu pumps, discusses the structure and mechanism of Cu pumps in comparison to other P-type ATPases, and summarizes the current data on Cu pump regulation.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages670-675
Number of pages6
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

Keywords

  • Atox1
  • ATP7A
  • ATP7B
  • CopA
  • Copper
  • Copper chaperone
  • CxxC
  • Menkes Disease
  • P-type ATPase
  • Wilson's disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Hatori, Y., & Lutsenko, S. (2013). P-Type Pumps: Copper Pump. In Encyclopedia of Biological Chemistry: Second Edition (pp. 670-675). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-378630-2.00188-2