P-Type Pumps

Copper Pump

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cu-transporting ATPases or Cu pumps are essential for normal homeostasis of all living organisms. Their activity is required for microbial pathogenicity, pheromone sensing by plants, neuronal activity in mammals, and many other physiological processes. Cu pumps transport copper from the cytosol across membranes to maintain copper balance and deliver copper cofactor to cuproenzymes. Genetic mutations in human Cu pumps result in severe disorders, Menkes disease, and Wilson's disease. This article describes the biological roles of Cu pumps, discusses the structure and mechanism of Cu pumps in comparison to other P-type ATPases, and summarizes the current data on Cu pump regulation.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages670-675
Number of pages6
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

Fingerprint

Copper
Pumps
Adenosine Triphosphatases
Menkes Kinky Hair Syndrome
Physiological Phenomena
Hepatolenticular Degeneration
Pheromones
Cytosol
Virulence
Mammals
Homeostasis
Mutation
Membranes

Keywords

  • Atox1
  • ATP7A
  • ATP7B
  • CopA
  • Copper
  • Copper chaperone
  • CxxC
  • Menkes Disease
  • P-type ATPase
  • Wilson's disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hatori, Y., & Lutsenko, S. (2013). P-Type Pumps: Copper Pump. In Encyclopedia of Biological Chemistry: Second Edition (pp. 670-675). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-378630-2.00188-2

P-Type Pumps : Copper Pump. / Hatori, Y.; Lutsenko, Svetlana.

Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., 2013. p. 670-675.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hatori, Y & Lutsenko, S 2013, P-Type Pumps: Copper Pump. in Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., pp. 670-675. https://doi.org/10.1016/B978-0-12-378630-2.00188-2
Hatori Y, Lutsenko S. P-Type Pumps: Copper Pump. In Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc. 2013. p. 670-675 https://doi.org/10.1016/B978-0-12-378630-2.00188-2
Hatori, Y. ; Lutsenko, Svetlana. / P-Type Pumps : Copper Pump. Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., 2013. pp. 670-675
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