Ozone-induced inflammation and altered ventilation in genetically susceptible mice: a comparison of acute and subacute exposures

Clarke G. Tankersley, Steven R. Kleeberger

Research output: Contribution to journalArticlepeer-review

Abstract

We have examined whether the effects of acute (2 ppm/3 h) and subacute (0.3 ppm/72 h) ozone (O3) exposures on airways are mutually predictive. Inbred C57BL/6J (susceptible) and C3H/HeJ (resistant) mice are differentially responsive to inflammation induced by the 2 exposures. Breeding experiments and cosegregation analysis indicated that 2 separate genes control inflammatory responses: Inf (acute), Inf-2 (subacute). The genetic model was also used to examine the effects of both exposures on the magnitude and pattern of breathing. Results imply that mechanisms that control susceptibility to the 2 exposures are not the same, and that one response is not necessarily predictive of the other.

Original languageEnglish (US)
Pages (from-to)279-289
Number of pages11
JournalToxicology Letters
Volume72
Issue number1-3
DOIs
StatePublished - Jun 1994

Keywords

  • Airways
  • Bronchoalveolar lavage
  • Control of breathing
  • Cosegregation analysis
  • Hypercapnia
  • Inbred mice

ASJC Scopus subject areas

  • Toxicology

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