Oxytocin for the treatment of drug and alcohol use disorders

Mary R. Lee, Elise Weerts

Research output: Contribution to journalArticle

Abstract

There is growing interest in the use of oxytocin (OT) as a potential treatment for alcohol and other substance-use disorders. OT is a neuropeptide that modulates adaptive processes associated with addiction including reward, tolerance, associative learning, memory, and stress responses. OT exerts its effects through interactions with the hypothalamic–pituitary–adrenal axis and multiple neurotransmitter systems including the dopamine mesolimbic reward and corticotrophin-releasing factor stress systems. The effects of OT on stress systems are of high interest, given the strong link between stress, drug use and relapse, and known dysregulation of hypothalamic–pituitary–adrenal-axis activity associated with substance-use disorders. At the same time, the OT system is itself altered by acute or chronic drug exposure. This review summarizes the preclinical and clinical literature on the OT system and its relevance to drug and alcohol addiction. In addition, findings from recent clinical trials conducted in participants with cocaine, cannabis, or alcohol use disorder are included and evidence that OT may help to normalize blunted stress responses, and attenuate withdrawal-associated hypercortisolism, negative mood, and withdrawal symptoms is summarized.

Original languageEnglish (US)
JournalBehavioural Pharmacology
DOIs
StateAccepted/In press - Sep 3 2016

Fingerprint

Oxytocin
Substance-Related Disorders
Alcohols
Reward
Substance Withdrawal Syndrome
Cushing Syndrome
Corticotropin-Releasing Hormone
Cannabis
Neuropeptides
Cocaine
Pharmaceutical Preparations
Alcoholism
Neurotransmitter Agents
Dopamine
Clinical Trials
Learning
Recurrence

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Oxytocin for the treatment of drug and alcohol use disorders. / Lee, Mary R.; Weerts, Elise.

In: Behavioural Pharmacology, 03.09.2016.

Research output: Contribution to journalArticle

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