TY - JOUR
T1 - Oxytocin and Social Adaptation
T2 - Insights from Neuroimaging Studies of Healthy and Clinical Populations
AU - Ma, Yina
AU - Shamay-Tsoory, Simone
AU - Han, Shihui
AU - Zink, Caroline F.
N1 - Funding Information:
This work was supported by startup funding from the State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning; Beijing Municipal Science & Technology Commission (Z151100003915122); and the National Natural Science Foundation of China (Projects 31421003, 31470986, 91332125).
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Adaptation to the social environment is critical for human survival. The neuropeptide oxytocin (OT), implicated in social cognition and emotions pivotal to sociality and well-being, is a promising pharmacological target for social and emotional dysfunction. We suggest here that the multifaceted role of OT in socio-affective processes improves the capability for social adaptation. We review OT effects on socio-affective processes, with a focus on OT-neuroimaging studies, to elucidate neuropsychological mechanisms through which OT promotes social adaptation. We also review OT-neuroimaging studies of individuals with social deficits and suggest that OT ameliorates impaired social adaptation by normalizing hyper- or hypo-brain activity. The social adaption model (SAM) provides an integrative understanding of discrepant OT effects and the modulations of OT action by personal milieu and context.
AB - Adaptation to the social environment is critical for human survival. The neuropeptide oxytocin (OT), implicated in social cognition and emotions pivotal to sociality and well-being, is a promising pharmacological target for social and emotional dysfunction. We suggest here that the multifaceted role of OT in socio-affective processes improves the capability for social adaptation. We review OT effects on socio-affective processes, with a focus on OT-neuroimaging studies, to elucidate neuropsychological mechanisms through which OT promotes social adaptation. We also review OT-neuroimaging studies of individuals with social deficits and suggest that OT ameliorates impaired social adaptation by normalizing hyper- or hypo-brain activity. The social adaption model (SAM) provides an integrative understanding of discrepant OT effects and the modulations of OT action by personal milieu and context.
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U2 - 10.1016/j.tics.2015.10.009
DO - 10.1016/j.tics.2015.10.009
M3 - Review article
C2 - 26616296
AN - SCOPUS:84959106023
SN - 1364-6613
VL - 20
SP - 133
EP - 145
JO - Trends in Cognitive Sciences
JF - Trends in Cognitive Sciences
IS - 2
ER -