Oxygenation in the rabbit myocardium: Assessment with susceptibility-dependent MR imaging

Michael K. Atalay, John R. Forder, V. P. Chacko, Satomi Kawamoto, Elias A. Zerhouni

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


PURPOSE: To determine the feasibility of using hemoglobin (Hb) desaturation as an indicator of myocardial oxygenation. MATERIALS AND METHODS: High-resolution gradient-echo nuclear magnetic resonance (MR) images of isolated, blood-perfused rabbit hearts were obtained at various blood oxygenation levels. The hearts were perfused at 37°C with a Langendorff apparatus modified for nuclear MR imaging. The perfusate contained bovine red blood cells in a cardioplegic solution that eliminated motion artifacts and minimized arteriovenous oxygenation differences. Hb saturation was varied (7%-100%) randomly. Perfusion pressure was continuously monitored, and blood samples were obtained. RESULTS: There was a substantial correlation between image signal intensity in the myocardium and Hb saturation in the blood, believed to be due to susceptibility effects of the paramagnetic species deoxyhemoglobin. CONCLUSION: Direct and noninvasive determination of regional Hb saturation with susceptibility-dependent MR imaging may provide information regarding regional myocardial O2 content.

Original languageEnglish (US)
Pages (from-to)759-764
Number of pages6
Issue number3
StatePublished - Dec 1993


  • Heart
  • Magnetic resonance (MR), pulse sequences, 57.12141
  • Myocardium, blood supply, 51.76
  • Oxygen

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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