Oxygen transport in a woman with hemoglobin Hope/β+ thalassemia

S. Charache, Stephen C Achuff, R. Winslow, Haig Kazazian

Research output: Contribution to journalArticle

Abstract

Because their blood may 'unload' oxygen more readily than normal, people with hemoglobin of low oxygen affinity might be expected to be anemic. We have studied a woman with hemoglobin Hope/β+ thalassemia, whose hemoglobin level was 10.4 to 12.3 gm/dl (normal 14 ± 2) despite a P50 of 41 mm Hg (normal 26). Her cardiac index was normal yielding a calculated mixed venous PO2 of 51 mm Hg (normal 34 to 49). Oxygen transport in patients with low oxygen affinity can be maintained by a variety of homeostatic responses, only one of which is altered erythropoiesis.

Original languageEnglish (US)
Pages (from-to)316-320
Number of pages5
JournalThe Journal of Laboratory and Clinical Medicine
Volume93
Issue number2
StatePublished - 1979

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Thalassemia
Oxygen
Hemoglobins
Erythropoiesis
Blood
hemoglobin Hope

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Oxygen transport in a woman with hemoglobin Hope/β+ thalassemia. / Charache, S.; Achuff, Stephen C; Winslow, R.; Kazazian, Haig.

In: The Journal of Laboratory and Clinical Medicine, Vol. 93, No. 2, 1979, p. 316-320.

Research output: Contribution to journalArticle

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AB - Because their blood may 'unload' oxygen more readily than normal, people with hemoglobin of low oxygen affinity might be expected to be anemic. We have studied a woman with hemoglobin Hope/β+ thalassemia, whose hemoglobin level was 10.4 to 12.3 gm/dl (normal 14 ± 2) despite a P50 of 41 mm Hg (normal 26). Her cardiac index was normal yielding a calculated mixed venous PO2 of 51 mm Hg (normal 34 to 49). Oxygen transport in patients with low oxygen affinity can be maintained by a variety of homeostatic responses, only one of which is altered erythropoiesis.

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