Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology

Research output: Contribution to journalArticle

Abstract

Hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis, which is disrupted in disorders affecting the circulatory system and in cancer. The role of HIFs in these diseases has been elucidated by clinical studies and by analyses of mouse models. HIFs play a protective role in the pathophysiology of myocardial ischemia due to coronary artery disease, limb ischemia due to peripheral arterial disease, pressure-overload heart failure, wound healing, and chronic rejection of organ transplants. In contrast, HIFs contribute to the pathogenesis of pulmonary arterial hypertension, systemic hypertension associated with sleep apnea, ocular neovascularization, hereditary erythrocytosis, and cancer.

Original languageEnglish (US)
Pages (from-to)47-71
Number of pages25
JournalAnnual Review of Pathology: Mechanisms of Disease
Volume9
DOIs
StatePublished - 2014

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pathophysiology
hypoxia
Oxygen
oxygen
hypertension
Activator Appliances
polycythemia
sleep apnea
organ transplantation
circulatory system
neoplasms
Peripheral Arterial Disease
Sleep Apnea Syndromes
heart failure
myocardial ischemia
ischemia
Cardiovascular System
angiogenesis
tissue repair
limbs (animal)

Keywords

  • Bronchiolitis obliterans
  • Cardioprotection
  • Collateral vessels
  • Polycythemia
  • Preconditioning
  • Retinopathy

ASJC Scopus subject areas

  • Plant Science
  • Medicine(all)

Cite this

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title = "Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology",
abstract = "Hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis, which is disrupted in disorders affecting the circulatory system and in cancer. The role of HIFs in these diseases has been elucidated by clinical studies and by analyses of mouse models. HIFs play a protective role in the pathophysiology of myocardial ischemia due to coronary artery disease, limb ischemia due to peripheral arterial disease, pressure-overload heart failure, wound healing, and chronic rejection of organ transplants. In contrast, HIFs contribute to the pathogenesis of pulmonary arterial hypertension, systemic hypertension associated with sleep apnea, ocular neovascularization, hereditary erythrocytosis, and cancer.",
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AB - Hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis, which is disrupted in disorders affecting the circulatory system and in cancer. The role of HIFs in these diseases has been elucidated by clinical studies and by analyses of mouse models. HIFs play a protective role in the pathophysiology of myocardial ischemia due to coronary artery disease, limb ischemia due to peripheral arterial disease, pressure-overload heart failure, wound healing, and chronic rejection of organ transplants. In contrast, HIFs contribute to the pathogenesis of pulmonary arterial hypertension, systemic hypertension associated with sleep apnea, ocular neovascularization, hereditary erythrocytosis, and cancer.

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