Oxygen sensing and homeostasis

Nanduri R. Prabhakar, Gregg L. Semenza

Research output: Contribution to journalReview articlepeer-review


The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology.

Original languageEnglish (US)
Pages (from-to)340-348
Number of pages9
Issue number5
StatePublished - Sep 1 2015

ASJC Scopus subject areas

  • Physiology

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