Oxygen sensing and homeostasis

Nanduri R. Prabhakar, Gregg L Semenza

Research output: Contribution to journalArticle

Abstract

The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology.

Original languageEnglish (US)
Pages (from-to)340-348
Number of pages9
JournalPhysiology
Volume30
Issue number5
DOIs
StatePublished - Sep 1 2015

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Homeostasis
Oxygen
Carotid Body
Sensory Receptor Cells
Gases
Maintenance
Pathology
Hypoxia

ASJC Scopus subject areas

  • Physiology

Cite this

Oxygen sensing and homeostasis. / Prabhakar, Nanduri R.; Semenza, Gregg L.

In: Physiology, Vol. 30, No. 5, 01.09.2015, p. 340-348.

Research output: Contribution to journalArticle

Prabhakar, Nanduri R. ; Semenza, Gregg L. / Oxygen sensing and homeostasis. In: Physiology. 2015 ; Vol. 30, No. 5. pp. 340-348.
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