Oxygen-responsive transcriptional regulation of lipid homeostasis in fungi: Implications for anti-fungal drug development

Research output: Contribution to journalReview articlepeer-review

Abstract

Low oxygen adaptation is essential for aerobic fungi that must survive in varied oxygen environments. Pathogenic fungi in particular must adapt to the low oxygen host tissue environment in order to cause infection. Maintenance of lipid homeostasis is especially important for cell growth and proliferation, and is a highly oxygen-dependent process. In this review, we focus on recent advances in our understanding of the transcriptional regulation and coordination of the low oxygen response across fungal species, paying particular attention to pathogenic fungi. Comparison of lipid homeostasis pathways in these organisms suggests common mechanisms of transcriptional regulation and points toward untapped potential to target low oxygen adaptation in antifungal development.

Original languageEnglish (US)
Pages (from-to)110-120
Number of pages11
JournalSeminars in Cell and Developmental Biology
Volume81
DOIs
StatePublished - Sep 2018

Keywords

  • Anti-fungal drug
  • Fungi
  • Hypoxia
  • Lipid metabolism
  • Transcription

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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