Abstract
Low oxygen adaptation is essential for aerobic fungi that must survive in varied oxygen environments. Pathogenic fungi in particular must adapt to the low oxygen host tissue environment in order to cause infection. Maintenance of lipid homeostasis is especially important for cell growth and proliferation, and is a highly oxygen-dependent process. In this review, we focus on recent advances in our understanding of the transcriptional regulation and coordination of the low oxygen response across fungal species, paying particular attention to pathogenic fungi. Comparison of lipid homeostasis pathways in these organisms suggests common mechanisms of transcriptional regulation and points toward untapped potential to target low oxygen adaptation in antifungal development.
Original language | English (US) |
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Pages (from-to) | 110-120 |
Number of pages | 11 |
Journal | Seminars in Cell and Developmental Biology |
Volume | 81 |
DOIs | |
State | Published - Sep 2018 |
Keywords
- Anti-fungal drug
- Fungi
- Hypoxia
- Lipid metabolism
- Transcription
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology