Abstract
The transcription factors nuclear factor interleukin-6 (NF-IL6), early growth response-1 (EGR-1) and hypoxia-inducible factor-1 (HIF-1) have important roles in the molecular pathophysiology of hypoxia-associated pulmonary disease. NF-IL6 controls the production of interleukin (IL)-6 in vascular endothelial cells, which may have anti-inflammatory activity by counteracting effects of IL-1 and IL-8. EGR-1 controls the production of tissue factor by macrophages, which triggers fibrin deposition in the pulmonary vasculature. HIF-1 activates the expression of the vasoconstrictor endothelin-1 in vascular endothelial cells. Angiotensin II induces HIF-1 expression and hypertrophy of pulmonary arterial smooth muscle cells. HIF-1 might therefore have multiple roles in the pathogenesis of pulmonary vascular remodeling.
Original language | English (US) |
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Pages (from-to) | 159-162 |
Number of pages | 4 |
Journal | Respiratory research |
Volume | 1 |
Issue number | 1 |
DOIs | |
State | Published - Nov 9 2000 |
Keywords
- EGR-1
- HIF-1
- NF-IL6
- Vascular remodeling
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine