Oxygen homeostasis

Research output: Contribution to journalReview articlepeer-review


Metazoan life is dependent upon the utilization of O2 for essential metabolic processes and oxygen homeostasis is an organizing principle for understanding metazoan evolution, ontology, physiology, and pathology. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that is expressed by all metazoan species and functions as a master regulator of oxygen homeostasis. Recent studies have elucidated complex mechanisms by which HIF-1 activity is regulated and by which HIF-1 regulates gene expression, with profound consequences for prenatal development, postnatal physiology, and disease pathogenesis.

Original languageEnglish (US)
Pages (from-to)336-361
Number of pages26
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Issue number3
StatePublished - May 1 2010

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)


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