Oxygen homeostasis

Gregg L. Semenza

doi:10.1002/wsbm.69

Oxygen homeostasis

Gregg L. Semenza

School of Medicine

Research output: Contribution to journal › Review article › peer-review

238 Scopus citations

Abstract

Metazoan life is dependent upon the utilization of O₂ for essential metabolic processes and oxygen homeostasis is an organizing principle for understanding metazoan evolution, ontology, physiology, and pathology. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that is expressed by all metazoan species and functions as a master regulator of oxygen homeostasis. Recent studies have elucidated complex mechanisms by which HIF-1 activity is regulated and by which HIF-1 regulates gene expression, with profound consequences for prenatal development, postnatal physiology, and disease pathogenesis.

Original language	English (US)
Pages (from-to)	336-361
Number of pages	26
Journal	Wiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume	2
Issue number	3
DOIs	https://doi.org/10.1002/wsbm.69
State	Published - May 2010

ASJC Scopus subject areas

General Medicine

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10.1002/wsbm.69

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AB - Metazoan life is dependent upon the utilization of O2 for essential metabolic processes and oxygen homeostasis is an organizing principle for understanding metazoan evolution, ontology, physiology, and pathology. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that is expressed by all metazoan species and functions as a master regulator of oxygen homeostasis. Recent studies have elucidated complex mechanisms by which HIF-1 activity is regulated and by which HIF-1 regulates gene expression, with profound consequences for prenatal development, postnatal physiology, and disease pathogenesis.

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Oxygen homeostasis

Abstract

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