Oxygen-dependent signaling in pulmonary vascular smooth muscle

Usha Raj, Larissa Shimoda

Research output: Contribution to journalReview articlepeer-review

Abstract

The pulmonary circulation constricts in response to acute hypoxia, which is reversible on reexposure to oxygen. On exposure to chronic hypoxia, in addition to vasoconstriction, the pulmonary vasculature undergoes remodeling, resulting in a sustained increase in pulmonary vascular resistance that is not immediately reversible. Hypoxic pulmonary vasoconstriction is physiological in the fetus, and there are many mechanisms by which the pulmonary vasculature relaxes at birth, principal among which is the acute increase in oxygen. Oxygen-induced signaling mechanisms, which result in pulmonary vascular relaxation at birth, and the mechanisms by which chronic hypoxia results in pulmonary vascular remodeling in the fetus and adult, are being investigated. Here, the roles of cGMP-dependent protein kinase in oxygen-mediated signaling in fetal pulmonary vascular smooth muscle and the effects of chronic hypoxia on ion channel activity and smooth muscle function such as contraction, growth, and gene expression were discussed.

Original languageEnglish (US)
Pages (from-to)L671-L677
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume283
Issue number4 27-4
DOIs
StatePublished - Oct 2002

Keywords

  • Fetal and neonatal pulmonary circulation
  • Hypoxia-inducible factor 1
  • Potassium channels
  • Pulmonary vascular remodeling

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology

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