Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen

Shinsuke Ohta, Ernst Meyer, Christopher J. Thompson, Albert Gjedde

Research output: Contribution to journalArticle

Abstract

We measured the rate of washout of 15O-labeled water generated from labeled oxygen accumulated in brain after bolus [15O]O2 inhalation, and compared the washout with that of labeled water measured with H215O. Contrary to the original expectation, the radioactive water generated from labeled oxygen failed to leave the brain tissue at the rate predicted by exogenous water. Therefore, the use of a separately measured value for exogenous water clearance led to an error in the calculation of oxygen consumption. A new method presented in this paper eliminated the error by yielding oxygen consumption in a single oxygen study. We used time-weighted integration to estimate three parameters, including the unidirectional clearance from blood to brain (K1O2), the fractional clearance of the distribution volume in brain (k2O2), and the vascular volume correction (Vo). We showed that the clearance of oxygen from blood to brain can be estimated with acceptable precision by this new approach, and that the new method yields a reliable measure of oxygen consumption.

Original languageEnglish (US)
Pages (from-to)179-192
Number of pages14
JournalJournal of Cerebral Blood Flow and Metabolism
Volume12
Issue number2
StatePublished - 1992
Externally publishedYes

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Oxygen Consumption
Inhalation
Electrons
Oxygen
Water
Brain
Blood Vessels

Keywords

  • Oxygen consumption
  • Positron emission tomography
  • Single oxygen study
  • Time-weighted integration method
  • Unidirectional clearance of oxygen

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

Cite this

Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen. / Ohta, Shinsuke; Meyer, Ernst; Thompson, Christopher J.; Gjedde, Albert.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 12, No. 2, 1992, p. 179-192.

Research output: Contribution to journalArticle

Ohta, Shinsuke ; Meyer, Ernst ; Thompson, Christopher J. ; Gjedde, Albert. / Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen. In: Journal of Cerebral Blood Flow and Metabolism. 1992 ; Vol. 12, No. 2. pp. 179-192.
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