Oxygen consumption of human blood platelets. I. Effect of thrombin

Joseph Muenzer, Eugene C. Weinbach, Sidney M. Wolfe

Research output: Contribution to journalArticlepeer-review


The effect of thrombin on the oxygen consumption of washed human platelets was measured polarographically with the Clark oxygen electrode. The average basal respiratory rate was 18±1.6 (mean ±S.E.) natoms oxygen per min per 109 platelets. Thrombin (1.9 units/ml) caused a 4-13-fold increase in the rate of oxygen consumption (138±14 (mean ±S.E.) natoms oxygen per min per 109 platelets). The thrombin-stimulated increase of oxygen consumption was transient, lasting from 1 to 1.5 min before returning to the respiratory rate observed before the thrombin addition. Release of platelet constituents appeared to precede the stimulation of oxygen consumption. These results may provide a basis for explaining the discrepancy in the literature concerning the effects of thrombin on platelet respiration.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalBBA - Bioenergetics
Issue number2
StatePublished - Feb 17 1975

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology


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