Oxygen consumption of cerebral cortex fails to increase during continued vibrotactile stimulation

Hitoshi Fujita, Hiroto Kuwabara, David C. Reutens, Albert Gjedde

Research output: Contribution to journalArticle

Abstract

The coupling of oxidative metabolism to the blood flow of the sensory motor hand area is uncertain. The authors tested the hypothesis that continued vibrotactile stimulation ultimately must lead to increased oxygen consumption consumption. Twenty-two healthy right-handed young volunteers underwent positron emission tomography (PET) with the [15O]water bolus injection method to measure water clearance (K2/(H2O) an index of blood flow (CBF), and with the [15O]oxygen bolus inhalation method to measure CMR(O2). The CMR(O2) was measured 30 seconds and 20 minutes after onset of intermittent (1 second on, 1 second off) vibrotactile stimulation (110 Hz) and compared with baseline measurements without stimulation. The K1/(H2O) and CMR(O2) changes (ΔK1/(H2O) and ΔCMR(O2)) were determined using intersubject averaging, together with magnetic resonance imaging based stereotaxic registration technique. The K1/(H2O) increase was 21 ± 4% and 12 ± 4% at 30 seconds and 20 minutes after onset of stimulation, respectively. No significant increase of CMR(O2) was found until 30 minutes after the onset of stimulation. The authors conclude that blood flow and oxidative metabolism undergo uncoupling during sustained phasic stimulation of the sensory hand area. Therefore, neuronal activity stimulated in this manner does not rely on significantly increased oxidative phosphorylation.

Original languageEnglish (US)
Pages (from-to)266-271
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Volume19
Issue number3
StatePublished - 1999
Externally publishedYes

Fingerprint

Oxygen Consumption
Cerebral Cortex
Hand
Stereotaxic Techniques
Oxidative Coupling
Water
Oxidative Phosphorylation
Positron-Emission Tomography
Inhalation
Volunteers
Magnetic Resonance Imaging
Oxygen
Injections
Sensorimotor Cortex

Keywords

  • Cerebral blood flow
  • Cerebral oxidative metabolism
  • Physiologic activation
  • Positron emission tomography
  • Vibrotactile stimulation

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

Cite this

Oxygen consumption of cerebral cortex fails to increase during continued vibrotactile stimulation. / Fujita, Hitoshi; Kuwabara, Hiroto; Reutens, David C.; Gjedde, Albert.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 19, No. 3, 1999, p. 266-271.

Research output: Contribution to journalArticle

@article{7f1ab945f0ca4ad1a5df1f87734195f9,
title = "Oxygen consumption of cerebral cortex fails to increase during continued vibrotactile stimulation",
abstract = "The coupling of oxidative metabolism to the blood flow of the sensory motor hand area is uncertain. The authors tested the hypothesis that continued vibrotactile stimulation ultimately must lead to increased oxygen consumption consumption. Twenty-two healthy right-handed young volunteers underwent positron emission tomography (PET) with the [15O]water bolus injection method to measure water clearance (K2/(H2O) an index of blood flow (CBF), and with the [15O]oxygen bolus inhalation method to measure CMR(O2). The CMR(O2) was measured 30 seconds and 20 minutes after onset of intermittent (1 second on, 1 second off) vibrotactile stimulation (110 Hz) and compared with baseline measurements without stimulation. The K1/(H2O) and CMR(O2) changes (ΔK1/(H2O) and ΔCMR(O2)) were determined using intersubject averaging, together with magnetic resonance imaging based stereotaxic registration technique. The K1/(H2O) increase was 21 ± 4{\%} and 12 ± 4{\%} at 30 seconds and 20 minutes after onset of stimulation, respectively. No significant increase of CMR(O2) was found until 30 minutes after the onset of stimulation. The authors conclude that blood flow and oxidative metabolism undergo uncoupling during sustained phasic stimulation of the sensory hand area. Therefore, neuronal activity stimulated in this manner does not rely on significantly increased oxidative phosphorylation.",
keywords = "Cerebral blood flow, Cerebral oxidative metabolism, Physiologic activation, Positron emission tomography, Vibrotactile stimulation",
author = "Hitoshi Fujita and Hiroto Kuwabara and Reutens, {David C.} and Albert Gjedde",
year = "1999",
language = "English (US)",
volume = "19",
pages = "266--271",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Oxygen consumption of cerebral cortex fails to increase during continued vibrotactile stimulation

AU - Fujita, Hitoshi

AU - Kuwabara, Hiroto

AU - Reutens, David C.

AU - Gjedde, Albert

PY - 1999

Y1 - 1999

N2 - The coupling of oxidative metabolism to the blood flow of the sensory motor hand area is uncertain. The authors tested the hypothesis that continued vibrotactile stimulation ultimately must lead to increased oxygen consumption consumption. Twenty-two healthy right-handed young volunteers underwent positron emission tomography (PET) with the [15O]water bolus injection method to measure water clearance (K2/(H2O) an index of blood flow (CBF), and with the [15O]oxygen bolus inhalation method to measure CMR(O2). The CMR(O2) was measured 30 seconds and 20 minutes after onset of intermittent (1 second on, 1 second off) vibrotactile stimulation (110 Hz) and compared with baseline measurements without stimulation. The K1/(H2O) and CMR(O2) changes (ΔK1/(H2O) and ΔCMR(O2)) were determined using intersubject averaging, together with magnetic resonance imaging based stereotaxic registration technique. The K1/(H2O) increase was 21 ± 4% and 12 ± 4% at 30 seconds and 20 minutes after onset of stimulation, respectively. No significant increase of CMR(O2) was found until 30 minutes after the onset of stimulation. The authors conclude that blood flow and oxidative metabolism undergo uncoupling during sustained phasic stimulation of the sensory hand area. Therefore, neuronal activity stimulated in this manner does not rely on significantly increased oxidative phosphorylation.

AB - The coupling of oxidative metabolism to the blood flow of the sensory motor hand area is uncertain. The authors tested the hypothesis that continued vibrotactile stimulation ultimately must lead to increased oxygen consumption consumption. Twenty-two healthy right-handed young volunteers underwent positron emission tomography (PET) with the [15O]water bolus injection method to measure water clearance (K2/(H2O) an index of blood flow (CBF), and with the [15O]oxygen bolus inhalation method to measure CMR(O2). The CMR(O2) was measured 30 seconds and 20 minutes after onset of intermittent (1 second on, 1 second off) vibrotactile stimulation (110 Hz) and compared with baseline measurements without stimulation. The K1/(H2O) and CMR(O2) changes (ΔK1/(H2O) and ΔCMR(O2)) were determined using intersubject averaging, together with magnetic resonance imaging based stereotaxic registration technique. The K1/(H2O) increase was 21 ± 4% and 12 ± 4% at 30 seconds and 20 minutes after onset of stimulation, respectively. No significant increase of CMR(O2) was found until 30 minutes after the onset of stimulation. The authors conclude that blood flow and oxidative metabolism undergo uncoupling during sustained phasic stimulation of the sensory hand area. Therefore, neuronal activity stimulated in this manner does not rely on significantly increased oxidative phosphorylation.

KW - Cerebral blood flow

KW - Cerebral oxidative metabolism

KW - Physiologic activation

KW - Positron emission tomography

KW - Vibrotactile stimulation

UR - http://www.scopus.com/inward/record.url?scp=0033392096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033392096&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 266

EP - 271

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 3

ER -