Oxidized Low-Density Lipoprotein-β2-Glycoprotein I Complex But Not Free Oxidized LDL Is Associated With the Presence and Severity of Coronary Artery Disease

Kevin P. Bliden, Rahul Chaudhary, Luis R. Lopez, Rongras Damrongwatanasuk, Kirk Guyer, Martin G. Gesheff, Christopher J. Franzese, Himabindu Kaza, Udaya S. Tantry, Paul A. Gurbel

Research output: Contribution to journalArticle

Abstract

Oxidized low-density lipoprotein (oxLDL) and β2-glycoprotein I (β2GPI) have been identified in human atherosclerotic lesions and when complexed have been implicated as a pro-atherothrombotic antigen. We examined the association of free oxLDL and oxLDL-β2GPI complex in patients with coronary artery disease who underwent elective cardiac catheterization. Serum was collected from patients with suspected coronary artery disease immediately before elective cardiac catheterization who were either treated (n = 385) or not treated (n = 150) with statins and from healthy volunteers (n = 134). OxLDL and oxLDL-β2GPI complex levels were determined by enzyme-linked immunosorbent assay. Disease severity was defined angiographically as none-minimal (<20%), moderate (20% to 75%), and severe (>75%) luminal diameter obstruction of any major coronary vessel. Both oxLDL and oxLDL-β2GPI complex were lower in patients on statins (p <0.001). In statin-naive patients, oxLDL-β2GPI complex, but not free oxLDL, was associated with severe coronary artery disease (p = 0.036). However, no association was observed in patients on statins. LDL4 and triglycerides increased with oxLDL-β2GPI complex quartiles (p = 0.001). OxLDL-β2GPI complex (>0.32 U/ml) was predictive of severe atherosclerosis by receiver-operating characteristic curve analysis in statin-naive patients (area under the curve 0.66, p = 0.002). In conclusion, oxLDL-β2GPI appears more predictive of coronary artery disease severity than oxLDL alone in statin-naive patients.

Original languageEnglish (US)
Pages (from-to)673-678
Number of pages6
JournalAmerican Journal of Cardiology
Volume118
Issue number5
DOIs
StatePublished - 2016

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LDL Lipoproteins
Coronary Artery Disease
Glycoproteins
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiac Catheterization
Free Association
oxidized low density lipoprotein
ROC Curve
Area Under Curve
Atherosclerosis
Coronary Vessels
Healthy Volunteers
Enzyme-Linked Immunosorbent Assay
Antigens
Serum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Oxidized Low-Density Lipoprotein-β2-Glycoprotein I Complex But Not Free Oxidized LDL Is Associated With the Presence and Severity of Coronary Artery Disease. / Bliden, Kevin P.; Chaudhary, Rahul; Lopez, Luis R.; Damrongwatanasuk, Rongras; Guyer, Kirk; Gesheff, Martin G.; Franzese, Christopher J.; Kaza, Himabindu; Tantry, Udaya S.; Gurbel, Paul A.

In: American Journal of Cardiology, Vol. 118, No. 5, 2016, p. 673-678.

Research output: Contribution to journalArticle

Bliden, KP, Chaudhary, R, Lopez, LR, Damrongwatanasuk, R, Guyer, K, Gesheff, MG, Franzese, CJ, Kaza, H, Tantry, US & Gurbel, PA 2016, 'Oxidized Low-Density Lipoprotein-β2-Glycoprotein I Complex But Not Free Oxidized LDL Is Associated With the Presence and Severity of Coronary Artery Disease', American Journal of Cardiology, vol. 118, no. 5, pp. 673-678. https://doi.org/10.1016/j.amjcard.2016.06.023
Bliden, Kevin P. ; Chaudhary, Rahul ; Lopez, Luis R. ; Damrongwatanasuk, Rongras ; Guyer, Kirk ; Gesheff, Martin G. ; Franzese, Christopher J. ; Kaza, Himabindu ; Tantry, Udaya S. ; Gurbel, Paul A. / Oxidized Low-Density Lipoprotein-β2-Glycoprotein I Complex But Not Free Oxidized LDL Is Associated With the Presence and Severity of Coronary Artery Disease. In: American Journal of Cardiology. 2016 ; Vol. 118, No. 5. pp. 673-678.
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abstract = "Oxidized low-density lipoprotein (oxLDL) and β2-glycoprotein I (β2GPI) have been identified in human atherosclerotic lesions and when complexed have been implicated as a pro-atherothrombotic antigen. We examined the association of free oxLDL and oxLDL-β2GPI complex in patients with coronary artery disease who underwent elective cardiac catheterization. Serum was collected from patients with suspected coronary artery disease immediately before elective cardiac catheterization who were either treated (n = 385) or not treated (n = 150) with statins and from healthy volunteers (n = 134). OxLDL and oxLDL-β2GPI complex levels were determined by enzyme-linked immunosorbent assay. Disease severity was defined angiographically as none-minimal (<20{\%}), moderate (20{\%} to 75{\%}), and severe (>75{\%}) luminal diameter obstruction of any major coronary vessel. Both oxLDL and oxLDL-β2GPI complex were lower in patients on statins (p <0.001). In statin-naive patients, oxLDL-β2GPI complex, but not free oxLDL, was associated with severe coronary artery disease (p = 0.036). However, no association was observed in patients on statins. LDL4 and triglycerides increased with oxLDL-β2GPI complex quartiles (p = 0.001). OxLDL-β2GPI complex (>0.32 U/ml) was predictive of severe atherosclerosis by receiver-operating characteristic curve analysis in statin-naive patients (area under the curve 0.66, p = 0.002). In conclusion, oxLDL-β2GPI appears more predictive of coronary artery disease severity than oxLDL alone in statin-naive patients.",
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AU - Lopez, Luis R.

AU - Damrongwatanasuk, Rongras

AU - Guyer, Kirk

AU - Gesheff, Martin G.

AU - Franzese, Christopher J.

AU - Kaza, Himabindu

AU - Tantry, Udaya S.

AU - Gurbel, Paul A.

PY - 2016

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AB - Oxidized low-density lipoprotein (oxLDL) and β2-glycoprotein I (β2GPI) have been identified in human atherosclerotic lesions and when complexed have been implicated as a pro-atherothrombotic antigen. We examined the association of free oxLDL and oxLDL-β2GPI complex in patients with coronary artery disease who underwent elective cardiac catheterization. Serum was collected from patients with suspected coronary artery disease immediately before elective cardiac catheterization who were either treated (n = 385) or not treated (n = 150) with statins and from healthy volunteers (n = 134). OxLDL and oxLDL-β2GPI complex levels were determined by enzyme-linked immunosorbent assay. Disease severity was defined angiographically as none-minimal (<20%), moderate (20% to 75%), and severe (>75%) luminal diameter obstruction of any major coronary vessel. Both oxLDL and oxLDL-β2GPI complex were lower in patients on statins (p <0.001). In statin-naive patients, oxLDL-β2GPI complex, but not free oxLDL, was associated with severe coronary artery disease (p = 0.036). However, no association was observed in patients on statins. LDL4 and triglycerides increased with oxLDL-β2GPI complex quartiles (p = 0.001). OxLDL-β2GPI complex (>0.32 U/ml) was predictive of severe atherosclerosis by receiver-operating characteristic curve analysis in statin-naive patients (area under the curve 0.66, p = 0.002). In conclusion, oxLDL-β2GPI appears more predictive of coronary artery disease severity than oxLDL alone in statin-naive patients.

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