DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson’s Disease (PD). DJ-1 was reported to function as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress by modifying signaling pathways that regulate cell survival. Here we discuss our progress toward characterization of the DJ-1 function in the protection of RPE to oxidative stress.
- Oxidative stress
- Reactive oxygen species
- Retinal pigment epithelium
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)