Oxidative stress regulation by DJ-1 in the retinal pigment epithelium

Vera L. Bonilha, Mary E. Rayborn, Xiaoping Yang, Chengsong Xie, Huaibin Cai

    Research output: Contribution to journalArticlepeer-review

    Abstract

    DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson’s Disease (PD). DJ-1 was reported to function as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress by modifying signaling pathways that regulate cell survival. Here we discuss our progress toward characterization of the DJ-1 function in the protection of RPE to oxidative stress.

    Original languageEnglish (US)
    Pages (from-to)649-654
    Number of pages6
    JournalAdvances in experimental medicine and biology
    Volume801
    DOIs
    StatePublished - 2014

    Keywords

    • DJ-1
    • Histology
    • Oxidative stress
    • Reactive oxygen species
    • Retinal pigment epithelium

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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