TY - JOUR
T1 - Oxidative stress as a therapeutic target for the prevention and treatment of early age-related macular degeneration
AU - Jabbehdari, Sayena
AU - Handa, James T.
N1 - Funding Information:
Funding: This work was supported by an unrestricted grant to Wilmer Eye Institute by the Research to Prevent Blindness . J. T. H. is the Robert Bond Welch Professor.
PY - 2020
Y1 - 2020
N2 - Age-related macular degeneration, the leading cause of irreversible visual loss among older adults in developed countries, is a chronic, multifactorial, and progressive disease with the development of painless, central vision loss. Retinal pigment epithelial cell dysfunction is a core change in age-related macular degeneration that results from aging and the accumulated effects of genetic and environmental factors that, in part, is both caused by and leads to oxidative stress. In this review, we describe the role of oxidative stress, the cytoprotective oxidative stress pathways, and the impact of oxidative stress on critical cellular processes involved in age-related macular degeneration pathobiology. We also offer targeted therapy that may define how antioxidant therapy can either prevent or improve specific stages of age-related macular degeneration.
AB - Age-related macular degeneration, the leading cause of irreversible visual loss among older adults in developed countries, is a chronic, multifactorial, and progressive disease with the development of painless, central vision loss. Retinal pigment epithelial cell dysfunction is a core change in age-related macular degeneration that results from aging and the accumulated effects of genetic and environmental factors that, in part, is both caused by and leads to oxidative stress. In this review, we describe the role of oxidative stress, the cytoprotective oxidative stress pathways, and the impact of oxidative stress on critical cellular processes involved in age-related macular degeneration pathobiology. We also offer targeted therapy that may define how antioxidant therapy can either prevent or improve specific stages of age-related macular degeneration.
KW - age-related macular degeneration
KW - aging
KW - antioxidant therapy
KW - oxidative stress
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U2 - 10.1016/j.survophthal.2020.09.002
DO - 10.1016/j.survophthal.2020.09.002
M3 - Review article
C2 - 32961209
AN - SCOPUS:85094575131
JO - Survey of Ophthalmology
JF - Survey of Ophthalmology
SN - 0039-6257
ER -