Oxidative stress and chronic inflammation in osteoarthritis: Can NRF2 counteract these partners in crime?

Andrey S. Marchev, Petya A. Dimitrova, Andrew J. Burns, Rumen V. Kostov, Albena T. Dinkova-Kostova, Milen I. Georgiev

Research output: Contribution to journalArticle

Abstract

Osteoarthritis (OA) is an age-related joint degenerative disease associated with pain, joint deformity, and disability. The disease starts with cartilage damage but then progressively involves subchondral bone, causing an imbalance between osteoclast-driven bone resorption and osteoblast-driven remodeling. Here, we summarize the data for the role of oxidative stress and inflammation in OA pathology and discuss how these two processes are integrated during OA progression, as well as their contribution to abnormalities in cartilage/bone metabolism and integrity. At the cellular level, oxidative stress and inflammation are counteracted by transcription factor nuclear factor erythroid p45-related factor 2 (NRF2), and we describe the regulation of NRF2, highlighting its role in OA pathology. We also discuss the beneficial effect of some phytonutrients, including the therapeutic potential of NRF2 activation, in OA.

Original languageEnglish (US)
JournalAnnals of the New York Academy of Sciences
DOIs
StateAccepted/In press - 2017

Keywords

  • Inflammation
  • NRF2
  • Osteoarthritis
  • Phytochemicals
  • ROS

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Marchev, A. S., Dimitrova, P. A., Burns, A. J., Kostov, R. V., Dinkova-Kostova, A. T., & Georgiev, M. I. (Accepted/In press). Oxidative stress and chronic inflammation in osteoarthritis: Can NRF2 counteract these partners in crime? Annals of the New York Academy of Sciences. https://doi.org/10.1111/nyas.13407