Oxidation of tyrosine to dopachrome by peroxidase isolated from murine melanoma.

M. R. Okun, L. Schley, R. Ziegelstein, H. Blair

Research output: Contribution to journalArticlepeer-review

Abstract

Peroxidase, isolated from B16 mouse melanoma, converted tyrosine to dopachrome in the presence of either dopa or dihydroxyfumarate co-factor. A suspended homogenate of cloned, cultured B16 mouse melanoma cells also showed peroxidatic conversion of tyrosine to dopachrome in the presence of dihydroxyfumarate co-factor. The findings confirm previous histochemical, autoradiographic-histochemical, and EM-histochemical studies showing that melanoma peroxidase can convert tyrosine to melanin.

Original languageEnglish (US)
Pages (from-to)8-12
Number of pages5
JournalPhysiological chemistry and physics
Volume14
Issue number1
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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