Oxidants, oxidative stress and the biology of ageing

T. Finkel, N. J. Holbrook

Research output: Contribution to journalArticlepeer-review

Abstract

Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.

Original languageEnglish (US)
Pages (from-to)239-247
Number of pages9
JournalNature
Volume408
Issue number6809
DOIs
StatePublished - Nov 9 2000
Externally publishedYes

ASJC Scopus subject areas

  • General

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