Oxidants, metabolism, and stem cell biology

Jie Liu, Liu Cao, Toren Finkel

Research output: Contribution to journalArticle

Abstract

Adult stem cells persist throughout the lifetime of the organism and may therefore require specific mechanisms to limit the effects of chronic oxidative stress. Recently, several instructive genetic mouse models have demonstrated the unique susceptibility of stem cells to perturbations in metabolic or redox homeostasis. These results have implications not only for stem cell biology but also suggest a mechanistic link between intracellular oxidants and the decline in regenerative function that occurs as a normal consequence of aging.

Original languageEnglish (US)
Pages (from-to)2158-2162
Number of pages5
JournalFree Radical Biology and Medicine
Volume51
Issue number12
DOIs
StatePublished - Dec 15 2011
Externally publishedYes

Keywords

  • aging
  • mitochondria
  • redox
  • stem cell

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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