Adult stem cells persist throughout the lifetime of the organism and may therefore require specific mechanisms to limit the effects of chronic oxidative stress. Recently, several instructive genetic mouse models have demonstrated the unique susceptibility of stem cells to perturbations in metabolic or redox homeostasis. These results have implications not only for stem cell biology but also suggest a mechanistic link between intracellular oxidants and the decline in regenerative function that occurs as a normal consequence of aging.
|Original language||English (US)|
|Number of pages||5|
|Journal||Free Radical Biology and Medicine|
|State||Published - Dec 15 2011|
- stem cell
ASJC Scopus subject areas
- Physiology (medical)