Oxidants, metabolism, and stem cell biology

Jie Liu; Liu Cao; Toren Finkel

doi:10.1016/j.freeradbiomed.2011.10.434

Oxidants, metabolism, and stem cell biology

Jie Liu, Liu Cao, Toren Finkel

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Adult stem cells persist throughout the lifetime of the organism and may therefore require specific mechanisms to limit the effects of chronic oxidative stress. Recently, several instructive genetic mouse models have demonstrated the unique susceptibility of stem cells to perturbations in metabolic or redox homeostasis. These results have implications not only for stem cell biology but also suggest a mechanistic link between intracellular oxidants and the decline in regenerative function that occurs as a normal consequence of aging.

Original language	English (US)
Pages (from-to)	2158-2162
Number of pages	5
Journal	Free Radical Biology and Medicine
Volume	51
Issue number	12
DOIs	https://doi.org/10.1016/j.freeradbiomed.2011.10.434
State	Published - Dec 15 2011
Externally published	Yes

Keywords

aging
mitochondria
redox
stem cell

ASJC Scopus subject areas

Biochemistry
Physiology (medical)

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10.1016/j.freeradbiomed.2011.10.434

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AU - Cao, Liu

AU - Finkel, Toren

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AB - Adult stem cells persist throughout the lifetime of the organism and may therefore require specific mechanisms to limit the effects of chronic oxidative stress. Recently, several instructive genetic mouse models have demonstrated the unique susceptibility of stem cells to perturbations in metabolic or redox homeostasis. These results have implications not only for stem cell biology but also suggest a mechanistic link between intracellular oxidants and the decline in regenerative function that occurs as a normal consequence of aging.

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KW - mitochondria

KW - redox

KW - stem cell

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Oxidants, metabolism, and stem cell biology

Abstract

Keywords

ASJC Scopus subject areas

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