TY - JOUR
T1 - Oxford-MEST classification in IgA nephropathy patients
T2 - A report from Iran
AU - Nasri, Hamid
AU - Mortazavi, Mojgan
AU - Ghorbani, Ali
AU - Shahbazian, Heshmatollah
AU - Kheiri, Soleiman
AU - Baradaran, Azar
AU - Emami-Naieni, Afsoon
AU - Saffari, Maryam
AU - Mardani, Saeed
AU - Momeni, Ali
AU - Madihi, Yahya
AU - Baradaran-Ghahfarokhi, Milad
AU - Rafieian-Kopaie, Mahmoud
AU - Hedayati, Parin
AU - Baradaran, Shahzad
AU - Ardalan, Mohammadreza
AU - Sajjadieh, Shahram
AU - Assarzadegan, Naziheh
AU - Ahmadi Soleimani, Seyed Mohammad
AU - Tamadon, Mohamad Reza
N1 - Publisher Copyright:
© 2012, Society of Diabetic Nephropathy Prevention. All rights reserved.
PY - 2012
Y1 - 2012
N2 - Background: There is a limited knowledge about the morphological features of IgA nephropathy (IgAN)in the middle east region. Objectives: The objective of this study was to evaluate the spectrum of histopathological findings in IgAN patients at our laboratory. Patients and Methods: At this work, an observational study reported which was conducted on IgAN patients using the Oxford-MEST classification system. Results: In this survey, of 102 patients 71.6% were male. The mean age of the patients was 37.7 ± 13.6 years. Morphologic variables of MEST classification was as follows; M1: 90.2%, E: 32%, S: 67% also,T in grads I and II were in 30% and 19% respectively, while 51% were in grade zero. A significant difference was observed in segmental glomerulosclerosis (P=0.003) and interstitial fibrosis/tubular atrophy frequency distribution (P= 0.045), between males and females. Furthermore, it was found that mesangial hypercellularity was more prevalent in yonger patients. Moreover, there was a significant correlation between serum creatinine and crescents (P<0.001). There was also significant correlation of serum creatinine with segmental glomerulosclerosis (P<0.001). Conclusions: Higher prevalence of segmental glomerulosclerosis and interstitial fibrosis/ tubular atrophy, as the two of, four variables of Oxford-MEST classification of IgAN in male patients further attests that male gender is a risk factor in this disease. In this study the significant correlation between serum creatinine and crescent was in an agreement with previous studies and suggests for the probable accomodation of extracapillary proliferation as a new variable in MEST system.
AB - Background: There is a limited knowledge about the morphological features of IgA nephropathy (IgAN)in the middle east region. Objectives: The objective of this study was to evaluate the spectrum of histopathological findings in IgAN patients at our laboratory. Patients and Methods: At this work, an observational study reported which was conducted on IgAN patients using the Oxford-MEST classification system. Results: In this survey, of 102 patients 71.6% were male. The mean age of the patients was 37.7 ± 13.6 years. Morphologic variables of MEST classification was as follows; M1: 90.2%, E: 32%, S: 67% also,T in grads I and II were in 30% and 19% respectively, while 51% were in grade zero. A significant difference was observed in segmental glomerulosclerosis (P=0.003) and interstitial fibrosis/tubular atrophy frequency distribution (P= 0.045), between males and females. Furthermore, it was found that mesangial hypercellularity was more prevalent in yonger patients. Moreover, there was a significant correlation between serum creatinine and crescents (P<0.001). There was also significant correlation of serum creatinine with segmental glomerulosclerosis (P<0.001). Conclusions: Higher prevalence of segmental glomerulosclerosis and interstitial fibrosis/ tubular atrophy, as the two of, four variables of Oxford-MEST classification of IgAN in male patients further attests that male gender is a risk factor in this disease. In this study the significant correlation between serum creatinine and crescent was in an agreement with previous studies and suggests for the probable accomodation of extracapillary proliferation as a new variable in MEST system.
KW - Classification
KW - Glomerulosclerosis
KW - IgA nephropathy
KW - Interstitial fibrosis
KW - Proliferation
KW - Tubular atrophy
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U2 - 10.5812/jnp.7
DO - 10.5812/jnp.7
M3 - Article
AN - SCOPUS:84867271251
SN - 2251-8363
VL - 1
SP - 31
EP - 42
JO - Journal of Nephropathology
JF - Journal of Nephropathology
IS - 1
ER -