Oxazoles in Organic Chemistry. 2. Application to the Synthesis of Benzylisoquinoline Alkaloids

Alan P. Kozikowski, Anthony Ames

Research output: Contribution to journalLetter

Abstract

A conceptually new route to the benzylisoquinoline alkaloids has been devised. The reaction of 2-lithiooxazoles with aromatic aldehydes to generate the thermodynamically favored 2-substituted oxazoles constitutes the key step in this process. A single-pot two carbon-carbon bond-joining reaction leading to an oxazoline suitable for further transformation to a phenethylamide is also described.

Original languageEnglish (US)
Pages (from-to)2548-2550
Number of pages3
JournalJournal of Organic Chemistry
Volume45
Issue number12
DOIs
StatePublished - Sep 1 1980

ASJC Scopus subject areas

  • Organic Chemistry

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