A conceptually new route to the benzylisoquinoline alkaloids has been devised. The reaction of 2-lithiooxazoles with aromatic aldehydes to generate the thermodynamically favored 2-substituted oxazoles constitutes the key step in this process. A single-pot two carbon-carbon bond-joining reaction leading to an oxazoline suitable for further transformation to a phenethylamide is also described.
ASJC Scopus subject areas
- Organic Chemistry