Oxandrolone therapy in patients with Turnersyndrome

Maria D. Urban; Peter A. Lee; John P. Dorst; Leslie P. Plotnick; Claude J. Migeon

doi:10.1016/S0022-3476(79)80170-5

Oxandrolone therapy in patients with Turnersyndrome

Maria D. Urban, Peter A. Lee, John P. Dorst, Leslie P. Plotnick, Claude J. Migeon

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Long-term, low-dosage androgen treatment of patients with Turner syndrome results in more rapid growth and significantly greater adult height than in control patients who receive only estrogen for pubertal development. Seventeen patients treated with oxandrolone for one year and ten treated for two years had significantly greater growth velocities during than before treatment. Mean adult height of 25 patients treated with oxandrolone, fluoxymesterone, or both was significantly taller than the height of adult patients with Turner syndrome treated with estrogen only. Excessive skeletal maturation was not generally observed.

Original language	English (US)
Pages (from-to)	823-827
Number of pages	5
Journal	The Journal of pediatrics
Volume	94
Issue number	5
DOIs	https://doi.org/10.1016/S0022-3476(79)80170-5
State	Published - May 1979
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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title = "Oxandrolone therapy in patients with Turnersyndrome",

abstract = "Long-term, low-dosage androgen treatment of patients with Turner syndrome results in more rapid growth and significantly greater adult height than in control patients who receive only estrogen for pubertal development. Seventeen patients treated with oxandrolone for one year and ten treated for two years had significantly greater growth velocities during than before treatment. Mean adult height of 25 patients treated with oxandrolone, fluoxymesterone, or both was significantly taller than the height of adult patients with Turner syndrome treated with estrogen only. Excessive skeletal maturation was not generally observed.",

author = "Urban, {Maria D.} and Lee, {Peter A.} and Dorst, {John P.} and Plotnick, {Leslie P.} and Migeon, {Claude J.}",

note = "Funding Information: From the Department of Pediatrics, Division of Pediatric Endocrinology and the Department of Radiology, Division of Pediatric Radiology, The Johns Hopkins University and Hospital Supported by Research Grant AM-O0180, Traineeship Grant A M-O 7116 of the National Institutes of Health, United States Public Health Services, RR-OO52 from the General Clinical Research Centers Programs of the Division of Research Resources, National Institutes of Health. Dr. Urban is a Clinical Associate Physician of the General Clinical Research Centers Programs. *Reprint address: CMSC 3-110, The Johns Hopkins Hospital Baltimore, MD 21205.",

year = "1979",

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doi = "10.1016/S0022-3476(79)80170-5",

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T1 - Oxandrolone therapy in patients with Turnersyndrome

AU - Urban, Maria D.

AU - Lee, Peter A.

AU - Dorst, John P.

AU - Plotnick, Leslie P.

AU - Migeon, Claude J.

N1 - Funding Information: From the Department of Pediatrics, Division of Pediatric Endocrinology and the Department of Radiology, Division of Pediatric Radiology, The Johns Hopkins University and Hospital Supported by Research Grant AM-O0180, Traineeship Grant A M-O 7116 of the National Institutes of Health, United States Public Health Services, RR-OO52 from the General Clinical Research Centers Programs of the Division of Research Resources, National Institutes of Health. Dr. Urban is a Clinical Associate Physician of the General Clinical Research Centers Programs. *Reprint address: CMSC 3-110, The Johns Hopkins Hospital Baltimore, MD 21205.

PY - 1979/5

Y1 - 1979/5

N2 - Long-term, low-dosage androgen treatment of patients with Turner syndrome results in more rapid growth and significantly greater adult height than in control patients who receive only estrogen for pubertal development. Seventeen patients treated with oxandrolone for one year and ten treated for two years had significantly greater growth velocities during than before treatment. Mean adult height of 25 patients treated with oxandrolone, fluoxymesterone, or both was significantly taller than the height of adult patients with Turner syndrome treated with estrogen only. Excessive skeletal maturation was not generally observed.

AB - Long-term, low-dosage androgen treatment of patients with Turner syndrome results in more rapid growth and significantly greater adult height than in control patients who receive only estrogen for pubertal development. Seventeen patients treated with oxandrolone for one year and ten treated for two years had significantly greater growth velocities during than before treatment. Mean adult height of 25 patients treated with oxandrolone, fluoxymesterone, or both was significantly taller than the height of adult patients with Turner syndrome treated with estrogen only. Excessive skeletal maturation was not generally observed.

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Oxandrolone therapy in patients with Turnersyndrome

Abstract

ASJC Scopus subject areas

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