TY - JOUR
T1 - Ovine Maternal and Fetal Circulatory Responses to an Endoperoxide Analog
AU - Schwartz, David B.
AU - Phernetton, Terrance M.
AU - Stock, Michael K.
AU - Rankin, John H.G.
PY - 1982/10
Y1 - 1982/10
N2 - There are extensive data on the circulatory responses to prostaglandins during pregnancy, but little is known about the precursor endoperoxides. The endoperoxide analog (15S)-hydroxy-9α, 11α-(epoxymethano)prosta-5Z, 13E-dienoic acid (EPA1) was used to evaluate the circulatory effects of endoperoxides in pregnant sheep. Ten near-term ewes and their fetuses were chronically catheterized to permit the measurement of regional blood flows by the radioactive microsphere method. In five sheep a fetal IV bolus injection of 12.5 μg/kg EPA1 produced a significant increase in fetal blood pressure from 43 to 51 mm Hg, vascular resistance of the cotyledons from 0.06 to 0.09 PRU·kg−1, membranes from 0.84 to 3.15 PRU·kg−1, and kidneys from 1.18 to 1.94 PRU·kg−1. In five sheep a 10-min maternal infusion of 0.5 μg/kg/min EPA1 produced a significant increase in blood pressure from 89.0 to 115.0 mm Hg, resistance of the uterus from 0.49 to 1.10 PRU, and kidneys from 0.13 to 0.20 PRU. There was no significant change in maternal cotyledonary resistance. It is evident from these results that EPA1 causes widespread vasoconstriction. In the placenta, however, there is vasoconstriction on the fetal side but the resistance of the maternal vascular bed is unaltered.
AB - There are extensive data on the circulatory responses to prostaglandins during pregnancy, but little is known about the precursor endoperoxides. The endoperoxide analog (15S)-hydroxy-9α, 11α-(epoxymethano)prosta-5Z, 13E-dienoic acid (EPA1) was used to evaluate the circulatory effects of endoperoxides in pregnant sheep. Ten near-term ewes and their fetuses were chronically catheterized to permit the measurement of regional blood flows by the radioactive microsphere method. In five sheep a fetal IV bolus injection of 12.5 μg/kg EPA1 produced a significant increase in fetal blood pressure from 43 to 51 mm Hg, vascular resistance of the cotyledons from 0.06 to 0.09 PRU·kg−1, membranes from 0.84 to 3.15 PRU·kg−1, and kidneys from 1.18 to 1.94 PRU·kg−1. In five sheep a 10-min maternal infusion of 0.5 μg/kg/min EPA1 produced a significant increase in blood pressure from 89.0 to 115.0 mm Hg, resistance of the uterus from 0.49 to 1.10 PRU, and kidneys from 0.13 to 0.20 PRU. There was no significant change in maternal cotyledonary resistance. It is evident from these results that EPA1 causes widespread vasoconstriction. In the placenta, however, there is vasoconstriction on the fetal side but the resistance of the maternal vascular bed is unaltered.
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U2 - 10.3181/00379727-171-41475
DO - 10.3181/00379727-171-41475
M3 - Article
C2 - 7145937
AN - SCOPUS:0020353119
VL - 171
SP - 46
EP - 49
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
SN - 0037-9727
IS - 1
ER -