TY - JOUR
T1 - Overweight and human immunodeficiency virus (HIV) progression in women
T2 - Associations HIV disease progression and changes in body mass index in women in the HIV epidemiology research study cohort
AU - Jones, Clara Y.
AU - Hogan, Joseph W.
AU - Snyder, Brad
AU - Klein, Robert S.
AU - Rompalo, Anne
AU - Schuman, Paula
AU - Carpenter, Charles C.
N1 - Funding Information:
Financial support: National Institutes of Health (supplemental grant 2P01-DK-45734-06 and grants R01-AI50505 P30-AI42853, and 1P01-DK-45734-01A2); Lifespan/Tufts/Brown Center for AIDS Research; Centers for Disease Control and Prevention (cooperative agreements U64/CCU106795, U64/CCU206798, U64/ CCU306802, and U64/CCU506831).
PY - 2003/9/1
Y1 - 2003/9/1
N2 - An association of increased weight with a slower progression of human immunodeficiency virus (HIV) disease has been reported in studies that have not included large numbers of women. We evaluated the association of HIV disease progression with body mass index (BMI) in 871 women and present cross-sectional, survival, and longitudinal analyses. A higher baseline BMI was associated with a lower rate of occurrence of the first CD4 cell count <200 cells/mm 3. In analyses that incorporated time-varying BMI, underweight and normal women had an increased risk of clinical acquired immune deficiency syndrome, and underweight women had increased risk of HIV-related death, compared with obese women. The association between change in BMI and CD4 cell count was estimated; increases in BMI were associated with slight increases in CD4 cell counts, even after controlling for prior values of CD4 cell count, viral load, and treatment. Higher BMI and increases in BMI are associated with a decreased risk of HIV progression.
AB - An association of increased weight with a slower progression of human immunodeficiency virus (HIV) disease has been reported in studies that have not included large numbers of women. We evaluated the association of HIV disease progression with body mass index (BMI) in 871 women and present cross-sectional, survival, and longitudinal analyses. A higher baseline BMI was associated with a lower rate of occurrence of the first CD4 cell count <200 cells/mm 3. In analyses that incorporated time-varying BMI, underweight and normal women had an increased risk of clinical acquired immune deficiency syndrome, and underweight women had increased risk of HIV-related death, compared with obese women. The association between change in BMI and CD4 cell count was estimated; increases in BMI were associated with slight increases in CD4 cell counts, even after controlling for prior values of CD4 cell count, viral load, and treatment. Higher BMI and increases in BMI are associated with a decreased risk of HIV progression.
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U2 - 10.1086/375889
DO - 10.1086/375889
M3 - Article
C2 - 12942377
AN - SCOPUS:0042337315
VL - 37
SP - S69-S80
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - SUPPL. 2
ER -