Overview of the Intersection of Genomics of Cholesterol Metabolism and Cardiometabolic Disease with Reproductive Health, Especially in Women

Anthony M. DeAngelis, Meaghan Roy-O'Reilly, Annabelle Rodriguez-Oquendo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

About 15% of reproductive aged couples in the United States experience infertility, which is defined as the failure to achieve a successful pregnancy after 12. months or more of appropriate, timed, and unprotected intercourse or therapeutic donor insemination. According to the American Society for Reproductive Medicine, about 30% of infertility cases can be attributed to female causes, 30% to male factors, and the remaining cases involve a combination of male and female factors, in addition to unexplained causes. Understanding the various pathologic mechanisms underlying infertility represents an active area of research and serves as an important first step in our ability to treat this health problem.

Original languageEnglish (US)
Title of host publicationTranslational Cardiometabolic Genomic Medicine
PublisherElsevier Inc.
Pages251-282
Number of pages32
ISBN (Electronic)9780128004746
ISBN (Print)9780127999616
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • Cholesterol uptake
  • HDL
  • Infertility
  • Metabolism

ASJC Scopus subject areas

  • Medicine(all)

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