Overview of cellular mechanisms and signaling pathways of piceatannol

Yang Cao, Wanli Smith, Liang Yan, Lingbo Kong

Research output: Contribution to journalShort survey

Abstract

Stilbenoids are a group of naturally occurring phenolic compounds found in various plant spe-cies. They share a common backbone structure known as stilbene. However, differences in the nature and position of substituents have made it possible to produce many derivatives. Piceatannol [PT], a hydroxy-lated derivative from resveratrol, exerts various biological activities ranging from cancer prevention, car-dio-protection, neuro-protection, anti-diabetic, depigmentation and so on. Although positive results were obtained in most cell culture and animal studies, the relevant cellular and molecular mechanisms of cyto-kines and signaling pathway about their biological effects still unclear. Thus, in the current review, we focus on the latest findings of PT on cellular biology in order to better understand the underlying therapeutic mechanisms of PT among various diseases.

Original languageEnglish (US)
Pages (from-to)4-10
Number of pages7
JournalCurrent Stem Cell Research and Therapy
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2019

Keywords

  • Cell apoptosis
  • Cell cycle
  • Cellular and molecular mechanism
  • Cytokines
  • Piceatannol
  • Signaling pathway

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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