Overview of BCL-2 Family Proteins and Therapeutic Potentials

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

BCL-2 family proteins interact in a network that regulates apoptosis. The BH3 amino acid sequence motif serves to bind together this conglomerate protein family, both literally and figuratively. BH3 motifs are present in antiapoptotic and proapoptotic BCL-2 homologs, and in a separate group of unrelated BH3-only proteins often appended to the BCL-2 family. BH3-containing helices mediate many of their physical interactions to determine cell death versus survival, leading to the development of BH3 mimetics as therapeutics. Here we provide an overview of BCL-2 family interactions, their relevance in health and disease, and the progress toward regulating their interactions therapeutically.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages1-21
Number of pages21
DOIs
Publication statusPublished - Jan 1 2019

Publication series

NameMethods in Molecular Biology
Volume1877
ISSN (Print)1064-3745

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Keywords

  • Apoptosis
  • BAK
  • BAX
  • BCL-2
  • BCL-xL
  • BH3 mimetics
  • BH3-only
  • Navitoclax
  • Venetoclax

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Huska, J. D., Lamb, H. M., & Hardwick, J. M. (2019). Overview of BCL-2 Family Proteins and Therapeutic Potentials. In Methods in Molecular Biology (pp. 1-21). (Methods in Molecular Biology; Vol. 1877). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-8861-7_1