Overview of BCL-2 Family Proteins and Therapeutic Potentials

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

BCL-2 family proteins interact in a network that regulates apoptosis. The BH3 amino acid sequence motif serves to bind together this conglomerate protein family, both literally and figuratively. BH3 motifs are present in antiapoptotic and proapoptotic BCL-2 homologs, and in a separate group of unrelated BH3-only proteins often appended to the BCL-2 family. BH3-containing helices mediate many of their physical interactions to determine cell death versus survival, leading to the development of BH3 mimetics as therapeutics. Here we provide an overview of BCL-2 family interactions, their relevance in health and disease, and the progress toward regulating their interactions therapeutically.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages1-21
Number of pages21
DOIs
StatePublished - Jan 1 2019

Publication series

NameMethods in Molecular Biology
Volume1877
ISSN (Print)1064-3745

Fingerprint

Amino Acid Motifs
Proteins
Amino Acid Sequence
Cell Death
Therapeutics
Apoptosis
Health

Keywords

  • Apoptosis
  • BAK
  • BAX
  • BCL-2
  • BCL-xL
  • BH3 mimetics
  • BH3-only
  • Navitoclax
  • Venetoclax

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Huska, J. D., Lamb, H. M., & Hardwick, J. M. (2019). Overview of BCL-2 Family Proteins and Therapeutic Potentials. In Methods in Molecular Biology (pp. 1-21). (Methods in Molecular Biology; Vol. 1877). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-8861-7_1

Overview of BCL-2 Family Proteins and Therapeutic Potentials. / Huska, Jason D.; Lamb, Heather Michelle; Hardwick, J Marie.

Methods in Molecular Biology. Humana Press Inc., 2019. p. 1-21 (Methods in Molecular Biology; Vol. 1877).

Research output: Chapter in Book/Report/Conference proceedingChapter

Huska, JD, Lamb, HM & Hardwick, JM 2019, Overview of BCL-2 Family Proteins and Therapeutic Potentials. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1877, Humana Press Inc., pp. 1-21. https://doi.org/10.1007/978-1-4939-8861-7_1
Huska JD, Lamb HM, Hardwick JM. Overview of BCL-2 Family Proteins and Therapeutic Potentials. In Methods in Molecular Biology. Humana Press Inc. 2019. p. 1-21. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-8861-7_1
Huska, Jason D. ; Lamb, Heather Michelle ; Hardwick, J Marie. / Overview of BCL-2 Family Proteins and Therapeutic Potentials. Methods in Molecular Biology. Humana Press Inc., 2019. pp. 1-21 (Methods in Molecular Biology).
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