Overview of a HLA-Ig based "lego-like system" for T cell monitoring, modulation and expansion

Mathias Oelke; Jonathan P. Schneck

doi:10.1007/s12026-009-8156-z

Overview of a HLA-Ig based "lego-like system" for T cell monitoring, modulation and expansion

Mathias Oelke, Jonathan P. Schneck

School of Medicine

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Recent advances in molecular medicine have shown that soluble MHC-multimers can be valuable tools for both analysis and modulation of antigen-specific immune responses in vitro and in vivo. In this review, we describe the use of dimeric human and mouse major histocompatibility complexes, MHC-Ig, as part of an artificial Antigen-Presenting Cell (aAPC). MHC-Ig-based aAPC and its derivatives represent an exciting new platform technology for measuring and manipulating immune responses in vitro as well as in vivo. This new technology has the potential to help overcome many of the obstacles associated with limitations in current antigen-specific approaches of immunotherapy for the treatment of cancer, infectious diseases and autoimmunity.

Original language	English (US)
Pages (from-to)	248-256
Number of pages	9
Journal	Immunologic Research
Volume	47
Issue number	1-3
DOIs	https://doi.org/10.1007/s12026-009-8156-z
State	Published - Jul 2010

Keywords

Active and adoptive immunotherapy
CD8CTL
Class I HLA
HLA-Ig dimer
Infectious diseases
Tumors

ASJC Scopus subject areas

Immunology

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10.1007/s12026-009-8156-z

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abstract = "Recent advances in molecular medicine have shown that soluble MHC-multimers can be valuable tools for both analysis and modulation of antigen-specific immune responses in vitro and in vivo. In this review, we describe the use of dimeric human and mouse major histocompatibility complexes, MHC-Ig, as part of an artificial Antigen-Presenting Cell (aAPC). MHC-Ig-based aAPC and its derivatives represent an exciting new platform technology for measuring and manipulating immune responses in vitro as well as in vivo. This new technology has the potential to help overcome many of the obstacles associated with limitations in current antigen-specific approaches of immunotherapy for the treatment of cancer, infectious diseases and autoimmunity.",

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AB - Recent advances in molecular medicine have shown that soluble MHC-multimers can be valuable tools for both analysis and modulation of antigen-specific immune responses in vitro and in vivo. In this review, we describe the use of dimeric human and mouse major histocompatibility complexes, MHC-Ig, as part of an artificial Antigen-Presenting Cell (aAPC). MHC-Ig-based aAPC and its derivatives represent an exciting new platform technology for measuring and manipulating immune responses in vitro as well as in vivo. This new technology has the potential to help overcome many of the obstacles associated with limitations in current antigen-specific approaches of immunotherapy for the treatment of cancer, infectious diseases and autoimmunity.

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Overview of a HLA-Ig based "lego-like system" for T cell monitoring, modulation and expansion

Abstract

Keywords

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