Overview

Zachary E. Stine, Chi V. Dang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer is one of the leading causes of death. Cancer cells grow and multiply rapidly, causing them to have metabolic needs differing from those of more slowly dividing noncancerous cells [1]. While many quiescent cells need only to meet the energy demands required for homeostasis, cancer cells need to produce not only energy but also the cellular building blocks required for rapid growth. Cancer cells reprogram their metabolism to provide the components for macromolecular biosynthesis, i.e., nucleotides to produce new deoxyribonucleic acid, lipids to create new cell membranes, and ribosomes and amino acids required for increased protein production [1]. Cancer is challenging to treat due to its similarity to noncancerous cells and the high amount of inter-tumor and intra-tumor heterogeneity.

Original languageEnglish (US)
Title of host publicationMetabolism of Human Diseases: Organ Physiology and Pathophysiology
PublisherSpringer-Verlag Wien
Pages393-399
Number of pages7
ISBN (Print)9783709107157, 9783709107140
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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