Overexpression of c-met in the early stage of pancreatic carcinogenesis; altered expression is not sufficient for progression from chronic pancreatitis to pancreatic cancer

Jun Yu, Kenoki Ohuchida, Kazuhiro Mizumoto, Nami Ishikawa, Yasuhiro Ogura, Daisuke Yamada, Takuya Egami, Hayato Fujita, Seiji Ohashi, Eishi Nagai, Masao Tanaka

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To investigate c-met expression during early pancreatic carcinogenesis. Methods: We used 46 bulk tissues and 36 micro-dissected samples, including normal pancreas, chronic pancreatitis, and pancreatic cancer, for quantitative real-time reverse transcription-polymerase chain reaction. Results: In bulk tissue analyses, pancreatic cancer tissues expressed significantly higher levels of c-met than did chronic pancreatitis and normal pancreas tissues. c-met levels did not differ between chronic pancreatitis and normal pancreas tissues. In microdissection-based analyses, c-met was expressed at higher levels in microdissected pancreatic cancer cells and pancreatitis-affected epithelial cells than in normal ductal epithelial cells (both, P < 0.01). Interestingly, pancreatitis-affected epithelial cells expressed levels of c-met similar to those of pancreatic cancer cells. Conclusion: Overexpression of c-met occurs during the early stage of pancreatic carcinogenesis, and a single alteration of c-met expression is not sufficient for progression of chronic pancreatitis-affected epithelial cells to pancreatic cancer cells.

Original languageEnglish (US)
Pages (from-to)3878-3882
Number of pages5
JournalWorld Journal of Gastroenterology
Volume12
Issue number24
DOIs
StatePublished - Jun 28 2006
Externally publishedYes

Keywords

  • Chronic pancreatitis
  • Pancreatic cancer
  • Pancreatic carcinogenesis
  • c-met

ASJC Scopus subject areas

  • Gastroenterology

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