Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation

Janghee Woo, Juna Lee, Young Kwang Chae, Myoung Sook Kim, Jin Hyen Baek, Jong Chul Park, Min Joo Park, Ian M. Smith, Barry Trink, Edward Ratovitski, Taekyul Lee, Bumsoo Park, Se Jin Jang, Jean C. Soria, Joseph A. Califano, David Sidransky, Chulso Moon

Research output: Contribution to journalArticle

Abstract

Overexpression of several aquaporins has been reported in different types of human cancer but the role of AQPs in human carcinogenesis has not yet been clearly defined. Here, we demonstrate that ectopic expression of human AQP5 (hAQP5), a water channel expressed in lung, salivary glands, and kidney, induces many phenotypic changes characteristic of transformation both in vitro and in vivo. Furthermore, the cell proliferative ability of AQP5 appears to be dependent upon the phosphorylation of a cAMP-protein kinase (PKA) consensus site located in a cytoplasmic loop of AQP5. In addition, phosphorylation of the PKA consensus site was found to be phosphorylated preferentially in tumors. These findings altogether indicate that hAQP5 plays an important role in human carcinogenesis and, furthermore, provide an attractive therapeutic target.

Original languageEnglish (US)
Pages (from-to)54-62
Number of pages9
JournalCancer Letters
Volume264
Issue number1
DOIs
StatePublished - Jun 8 2008

Keywords

  • AQP5
  • Aquaporins
  • Overexpression

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Woo, J., Lee, J., Chae, Y. K., Kim, M. S., Baek, J. H., Park, J. C., Park, M. J., Smith, I. M., Trink, B., Ratovitski, E., Lee, T., Park, B., Jang, S. J., Soria, J. C., Califano, J. A., Sidransky, D., & Moon, C. (2008). Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation. Cancer Letters, 264(1), 54-62. https://doi.org/10.1016/j.canlet.2008.01.029