Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors: a single-center, single-surgeon experience

Aalap C. Shah, Kazimierz W. Komperda, Arun Mavanur, Steven W. Thorpe, Kurt R. Weiss, Mark A. Goodman

Research output: Contribution to journalArticle

Abstract

Background and objectives: Malignant primary chest wall tumors (PCWTs) comprise a rare group of thoracic tumors with unique anatomical considerations, and experience with wide surgical resection is limited to specialty referral centers and specific diagnoses. We investigated the tumor recurrence and overall survival (OS) for patients with a variety of PCWTs diagnoses at our institution. Methods: From 1991 to 2010, patients with malignant PCWT undergoing wide surgical resection for curative intent under a single surgeon were reviewed. Diagnosis and grade (if applicable) of surgical pathology, along with patient demographics, neoadjuvant chemotherapy or radiation therapy, and outcomes (complications, recurrence, and OS) at follow-up were analyzed. Results: One hundred fifteen patients were included in the study. The most common tumor diagnoses included pleomorphic sarcoma and liposarcoma. Negative margins were achieved in 70 (74%) of cases. Postoperative complications were reported in 21 (20%) cases. The 5-year survival rate was 54%, while the 10-year survival rate was 29%. The local and distant recurrence rates were 50% and 38%, respectively. OS was significantly less in patients with any recurrence (p < 0.001) but not significantly different between pathology grades (p = 0.28). Conclusions: Wide resection for malignant PCWT is feasible when undertaken for a heterogenous group of diagnoses.

Original languageEnglish (US)
JournalJournal of Orthopaedic Surgery
Volume27
Issue number2
DOIs
StatePublished - May 1 2019
Externally publishedYes

Fingerprint

Thoracic Wall
Recurrence
Survival
Neoplasms
Survival Rate
Liposarcoma
Surgical Pathology
Neoadjuvant Therapy
Surgeons
Sarcoma
Radiotherapy
Thorax
Referral and Consultation
Demography
Pathology
Drug Therapy

Keywords

  • chest wall tumors
  • overall survival
  • postoperative outcomes
  • tumor recurrence

ASJC Scopus subject areas

  • Surgery

Cite this

Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors : a single-center, single-surgeon experience. / Shah, Aalap C.; Komperda, Kazimierz W.; Mavanur, Arun; Thorpe, Steven W.; Weiss, Kurt R.; Goodman, Mark A.

In: Journal of Orthopaedic Surgery, Vol. 27, No. 2, 01.05.2019.

Research output: Contribution to journalArticle

@article{597cec28de3448eeb17a78fb1aba5e42,
title = "Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors: a single-center, single-surgeon experience",
abstract = "Background and objectives: Malignant primary chest wall tumors (PCWTs) comprise a rare group of thoracic tumors with unique anatomical considerations, and experience with wide surgical resection is limited to specialty referral centers and specific diagnoses. We investigated the tumor recurrence and overall survival (OS) for patients with a variety of PCWTs diagnoses at our institution. Methods: From 1991 to 2010, patients with malignant PCWT undergoing wide surgical resection for curative intent under a single surgeon were reviewed. Diagnosis and grade (if applicable) of surgical pathology, along with patient demographics, neoadjuvant chemotherapy or radiation therapy, and outcomes (complications, recurrence, and OS) at follow-up were analyzed. Results: One hundred fifteen patients were included in the study. The most common tumor diagnoses included pleomorphic sarcoma and liposarcoma. Negative margins were achieved in 70 (74{\%}) of cases. Postoperative complications were reported in 21 (20{\%}) cases. The 5-year survival rate was 54{\%}, while the 10-year survival rate was 29{\%}. The local and distant recurrence rates were 50{\%} and 38{\%}, respectively. OS was significantly less in patients with any recurrence (p < 0.001) but not significantly different between pathology grades (p = 0.28). Conclusions: Wide resection for malignant PCWT is feasible when undertaken for a heterogenous group of diagnoses.",
keywords = "chest wall tumors, overall survival, postoperative outcomes, tumor recurrence",
author = "Shah, {Aalap C.} and Komperda, {Kazimierz W.} and Arun Mavanur and Thorpe, {Steven W.} and Weiss, {Kurt R.} and Goodman, {Mark A.}",
year = "2019",
month = "5",
day = "1",
doi = "10.1177/2309499019838296",
language = "English (US)",
volume = "27",
journal = "Journal of Orthopaedic Surgery",
issn = "1022-5536",
publisher = "Hong Kong Academy of Medicine Press",
number = "2",

}

TY - JOUR

T1 - Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors

T2 - a single-center, single-surgeon experience

AU - Shah, Aalap C.

AU - Komperda, Kazimierz W.

AU - Mavanur, Arun

AU - Thorpe, Steven W.

AU - Weiss, Kurt R.

AU - Goodman, Mark A.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Background and objectives: Malignant primary chest wall tumors (PCWTs) comprise a rare group of thoracic tumors with unique anatomical considerations, and experience with wide surgical resection is limited to specialty referral centers and specific diagnoses. We investigated the tumor recurrence and overall survival (OS) for patients with a variety of PCWTs diagnoses at our institution. Methods: From 1991 to 2010, patients with malignant PCWT undergoing wide surgical resection for curative intent under a single surgeon were reviewed. Diagnosis and grade (if applicable) of surgical pathology, along with patient demographics, neoadjuvant chemotherapy or radiation therapy, and outcomes (complications, recurrence, and OS) at follow-up were analyzed. Results: One hundred fifteen patients were included in the study. The most common tumor diagnoses included pleomorphic sarcoma and liposarcoma. Negative margins were achieved in 70 (74%) of cases. Postoperative complications were reported in 21 (20%) cases. The 5-year survival rate was 54%, while the 10-year survival rate was 29%. The local and distant recurrence rates were 50% and 38%, respectively. OS was significantly less in patients with any recurrence (p < 0.001) but not significantly different between pathology grades (p = 0.28). Conclusions: Wide resection for malignant PCWT is feasible when undertaken for a heterogenous group of diagnoses.

AB - Background and objectives: Malignant primary chest wall tumors (PCWTs) comprise a rare group of thoracic tumors with unique anatomical considerations, and experience with wide surgical resection is limited to specialty referral centers and specific diagnoses. We investigated the tumor recurrence and overall survival (OS) for patients with a variety of PCWTs diagnoses at our institution. Methods: From 1991 to 2010, patients with malignant PCWT undergoing wide surgical resection for curative intent under a single surgeon were reviewed. Diagnosis and grade (if applicable) of surgical pathology, along with patient demographics, neoadjuvant chemotherapy or radiation therapy, and outcomes (complications, recurrence, and OS) at follow-up were analyzed. Results: One hundred fifteen patients were included in the study. The most common tumor diagnoses included pleomorphic sarcoma and liposarcoma. Negative margins were achieved in 70 (74%) of cases. Postoperative complications were reported in 21 (20%) cases. The 5-year survival rate was 54%, while the 10-year survival rate was 29%. The local and distant recurrence rates were 50% and 38%, respectively. OS was significantly less in patients with any recurrence (p < 0.001) but not significantly different between pathology grades (p = 0.28). Conclusions: Wide resection for malignant PCWT is feasible when undertaken for a heterogenous group of diagnoses.

KW - chest wall tumors

KW - overall survival

KW - postoperative outcomes

KW - tumor recurrence

UR - http://www.scopus.com/inward/record.url?scp=85063994381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063994381&partnerID=8YFLogxK

U2 - 10.1177/2309499019838296

DO - 10.1177/2309499019838296

M3 - Article

C2 - 30939982

AN - SCOPUS:85063994381

VL - 27

JO - Journal of Orthopaedic Surgery

JF - Journal of Orthopaedic Surgery

SN - 1022-5536

IS - 2

ER -