Overactive bladder in adults with sickle cell disease

Uzoma A. Anele, Belinda F. Morrison, Marvin E. Reid, Wendy Madden, Shara Foster, Arthur Burnett

Research output: Contribution to journalArticle

Abstract

Aims: To characterize the prevalence and impact of nocturnal enuresis and overactive bladder (OAB) symptomatology in the adult sickle-cell disease (SCD) population. Methods: We performed a single-center, cross-sectional study of adult SCD patients from October 2012 to February 2014, using the validated Pfizer OAB short form questionnaire and brief voiding history surveys. Patient responses and scores were compared to that of controls having normal or sickle cell trait hemoglobin genotypes. Results: A group of 239 SCD patients (116 males, 123 females) were compared with 104 normal and 57 sickle cell trait patients. Seven of 239 (2.9%) SCD patients compared to none of the 161 patients without SCD (P = 0.04) reported current nocturnal enuresis. The median age of nocturnal enuresis cessation was higher in SCD patients (12.0, IQR 9.0–15.0 years) compared to that of both normal (7.5, IQR 6.0–9.8 years) and sickle cell trait (7.5, IQR 6.0–8.8 years) groups (P <0.0001). Ninety-three of 239 (38.9%) SCD patients compared to 17 of 104 (16.3%) normal and 11 of 57 (19.3%) sickle cell trait had scores indicating OAB symptomatology (P <0.0001). Patients with SCD had higher OAB symptom severity and lower health-related quality of life (HRQL) scores compared to the normal and sickle cell trait groups (P <0.0001 and P <0.0001, respectively). Conclusions: We demonstrate an elevated rate of nocturnal enuresis and OAB symptoms in the adult SCD population. An OAB phenotype may be an under-recognized complication of SCD irrespective of age. Neurourol. Urodynam. 35:642–646, 2016.

Original languageEnglish (US)
Pages (from-to)642-646
Number of pages5
JournalNeurourology and Urodynamics
Volume35
Issue number5
DOIs
StatePublished - Jun 1 2016

Fingerprint

Overactive Urinary Bladder
Sickle Cell Anemia
Sickle Cell Trait
Nocturnal Enuresis
Population
Hemoglobins
Cross-Sectional Studies
History
Genotype
Quality of Life
Phenotype

Keywords

  • epidemiology
  • nocturnal enuresis
  • population-based
  • prevalence
  • quality of life

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology

Cite this

Anele, U. A., Morrison, B. F., Reid, M. E., Madden, W., Foster, S., & Burnett, A. (2016). Overactive bladder in adults with sickle cell disease. Neurourology and Urodynamics, 35(5), 642-646. https://doi.org/10.1002/nau.22777

Overactive bladder in adults with sickle cell disease. / Anele, Uzoma A.; Morrison, Belinda F.; Reid, Marvin E.; Madden, Wendy; Foster, Shara; Burnett, Arthur.

In: Neurourology and Urodynamics, Vol. 35, No. 5, 01.06.2016, p. 642-646.

Research output: Contribution to journalArticle

Anele, UA, Morrison, BF, Reid, ME, Madden, W, Foster, S & Burnett, A 2016, 'Overactive bladder in adults with sickle cell disease', Neurourology and Urodynamics, vol. 35, no. 5, pp. 642-646. https://doi.org/10.1002/nau.22777
Anele, Uzoma A. ; Morrison, Belinda F. ; Reid, Marvin E. ; Madden, Wendy ; Foster, Shara ; Burnett, Arthur. / Overactive bladder in adults with sickle cell disease. In: Neurourology and Urodynamics. 2016 ; Vol. 35, No. 5. pp. 642-646.
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