Ovarian stimulation for in vitro fertilization in low-responder patients using pulsatile intravenous follicle stimulating hormone

Michael C. Edelstein, Robert G. Brzyski, Georgeanna S. Jones, Suheil J. Muasher

Research output: Contribution to journalArticlepeer-review

Abstract

There is a subset of patients who fail to respond adequately to exogenous gonadotropin stimulation for in vitro fertilization (IVF). In this study, six such low-responder patients who had inadequate stimulations with high-dose intramuscular (im) follicle stimulating hormone (FSH) were treated in a subsequent cycle with pulsatile intravenous (iv) FSH. A paired analysis was performed to compare the cycles using high-dose im FSH with those using pulsatile iv FSH. Trough serum FSH levels were significantly higher with pulsatile iv FSH. No significant difference was noted in the stimulation characteristics or the number or quality of oocytes retrieved and embryos transferred. No pregnancies occurred in either group. While pulsatile iv administration of gonadotropin increases serum FSH levels, it does not appear to have a major impact on follicular stimulation or outcome in low-responder patients undergoing IVF.

Original languageEnglish (US)
Pages (from-to)275-279
Number of pages5
JournalJournal of In Vitro Fertilization and Embryo Transfer
Volume7
Issue number5
DOIs
StatePublished - Oct 1 1990

Keywords

  • follicle stimulating hormone
  • in vitro fertilization
  • low responder
  • pulsatile gonadotropins

ASJC Scopus subject areas

  • Reproductive Medicine
  • Embryology
  • Obstetrics and Gynecology
  • Developmental Biology

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