TY - JOUR
T1 - Ovarian hyperthecosis in the adolescent patient
AU - Wentz, Anne Colston
AU - Gutai, James P.
AU - Jones, Georgeanna Seegar
AU - Migeon, Claude J.
N1 - Funding Information:
From the Division of Reproductive Endocrinology, Department of Gynecology and Obstetrics, and the Division of Pediatric Endocrinology, Department of Pediatrics, The Johns Hopkins University School of Medicine. Supported in part by United States Public Health Service Research Grant AM-00180-24 and Traineeship Grant AM-05219-15. *Reprint address: Department of Gynecology and Obstetrics, Room 424 - Woman's Clinic, The Johns Hopkins Hospital, Baltimore, Md. 21205. ** Recipient of Research Career A ward 5-KO6-AM-21855: 11.
PY - 1976/3
Y1 - 1976/3
N2 - The endocrine findings in two adolescents with hyperthecosis are compared to those in a patient with an androgenic ovarian tumor. In patients with hyperthecosis, luteinizing hormone values were elevated or in the upper normal range, and plasma testosterone and androstenedione values remained elevated, but after administration of human chorionic gonadotropin, they increased further in only one patient. Baseline 17-ketosteroid values were normal, suppressed with dexamethasone, and stimulated to baseline levels following HCG. The patient with a lipoid cell ovarian tumor had low baseline LH levels, and elevated testosterone, androstenedione, and 17-ketosteroid values. Dexamethasone produced little change in urinary or plasma values, but the 17-ketosteroids increased markedly after administration of HCG. The finding of low serum LH values in patients with hirsutism and elevated androgen secretion should alert the clinician to the possibility of a tumor.
AB - The endocrine findings in two adolescents with hyperthecosis are compared to those in a patient with an androgenic ovarian tumor. In patients with hyperthecosis, luteinizing hormone values were elevated or in the upper normal range, and plasma testosterone and androstenedione values remained elevated, but after administration of human chorionic gonadotropin, they increased further in only one patient. Baseline 17-ketosteroid values were normal, suppressed with dexamethasone, and stimulated to baseline levels following HCG. The patient with a lipoid cell ovarian tumor had low baseline LH levels, and elevated testosterone, androstenedione, and 17-ketosteroid values. Dexamethasone produced little change in urinary or plasma values, but the 17-ketosteroids increased markedly after administration of HCG. The finding of low serum LH values in patients with hirsutism and elevated androgen secretion should alert the clinician to the possibility of a tumor.
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U2 - 10.1016/S0022-3476(76)80276-4
DO - 10.1016/S0022-3476(76)80276-4
M3 - Article
C2 - 1107505
AN - SCOPUS:0017285312
SN - 0022-3476
VL - 88
SP - 488
EP - 493
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 3
ER -