TY - JOUR
T1 - Ovarian hyperandrogenism
T2 - The role of and sensitivity to gonadotropins
AU - McClamrock, H. D.
AU - Bass, K. M.
AU - Adashi, E. Y.
N1 - Funding Information:
Received July 9, 1990; revised and accepted August 14, 1990. *Presented in part at the 35th Annual Meeting of the Society for Gynecological Investigation, Baltimore, Maryland, March 17 to 20, 1988. t Supported in part by a grant from the Pangborn Fund, University of Maryland School of Medicine, Baltimore, Maryland. :j: Reprint requests: Howard D. McClamrock, M.D., Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, 405 W. Redwood Street, Third Floor, Baltimore, Maryland 21201.
PY - 1991
Y1 - 1991
N2 - To determine if ovarian hyperandrogenism represents enhanced gonadotropic stimulation, augmented ovarian sensitivity to gonadotropins, or both, we have undertaken to evaluate (1) the 24-hour integrated concentrations of serum total testosterone (T) and luteinizing hormone (LH) and (2) the ovarian response of T to exogenous gonadotropic stimulation. To this end, two groups of women, hyperandrogenic anovulatory (n = 4) and early follicular phase (n = 4) normally-cycling controls, were subjected to continuous blood withdrawal over 24 hours with a portable Cormed pump (Cormed Inc., Middleport, NY) and to exogenous stimulation with human chorionic gonadotropin. Our current observations support the notion that ovarian hyperandrogenism represents the combined impact of an overall increase in gonadotropic support coupled with augmented ovarian sensitivity to gonadotropic stimulation.
AB - To determine if ovarian hyperandrogenism represents enhanced gonadotropic stimulation, augmented ovarian sensitivity to gonadotropins, or both, we have undertaken to evaluate (1) the 24-hour integrated concentrations of serum total testosterone (T) and luteinizing hormone (LH) and (2) the ovarian response of T to exogenous gonadotropic stimulation. To this end, two groups of women, hyperandrogenic anovulatory (n = 4) and early follicular phase (n = 4) normally-cycling controls, were subjected to continuous blood withdrawal over 24 hours with a portable Cormed pump (Cormed Inc., Middleport, NY) and to exogenous stimulation with human chorionic gonadotropin. Our current observations support the notion that ovarian hyperandrogenism represents the combined impact of an overall increase in gonadotropic support coupled with augmented ovarian sensitivity to gonadotropic stimulation.
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U2 - 10.1016/s0015-0282(16)54062-x
DO - 10.1016/s0015-0282(16)54062-x
M3 - Article
C2 - 1986974
AN - SCOPUS:0026088544
SN - 0015-0282
VL - 55
SP - 73
EP - 79
JO - Fertility and sterility
JF - Fertility and sterility
IS - 1
ER -