Ovarian carcinogenesis: An alternative hypothesis

Jurgen M J Piek, Paul J. Van Diest, René H M Verheijen

Research output: Contribution to journalArticle

Abstract

Cancer of the ovary is among the most common female genital tract cancers and has the worst prognosis. This is largely caused by the fact that these cancers are detected at late stage of disease, because of absence of early clinical symptoms. Consequently, early events in ovarian carcinogenesis remain remarkably unknown. Therefore, the precursor cell of these tumours remains a matter of debate (1, 2). Three explanations as to the origin of serous ovarian adenocarcinomas have been put forward. The first one points towards the ovarian surface epithelium (OSE) as tissue of origin (3). Second, remnants of the embryologic Müllerian duct, the secondary Müllerian system, have been suggested as possible tissue of origin (4). The third is the Fallopian tube inner surface epithelium (TSE) (=oviduct epithelium) (1, 5). In this chapter, the third possible origin is highlighted.

Original languageEnglish (US)
Pages (from-to)79-87
Number of pages9
JournalAdvances in Experimental Medicine and Biology
Volume622
DOIs
StatePublished - 2008
Externally publishedYes

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Carcinogenesis
Epithelium
Tissue
Ducts
Tumors
Neoplasms
Oviducts
Fallopian Tubes
Ovarian Neoplasms
Adenocarcinoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Ovarian carcinogenesis : An alternative hypothesis. / Piek, Jurgen M J; Van Diest, Paul J.; Verheijen, René H M.

In: Advances in Experimental Medicine and Biology, Vol. 622, 2008, p. 79-87.

Research output: Contribution to journalArticle

Piek, Jurgen M J ; Van Diest, Paul J. ; Verheijen, René H M. / Ovarian carcinogenesis : An alternative hypothesis. In: Advances in Experimental Medicine and Biology. 2008 ; Vol. 622. pp. 79-87.
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