Outpatient therapy with oral ofloxacin for patients with low risk neutropenia and fever: A prospective, randomized clinical trial

Manuel Hidalgo, Javier Hornedo, Carlos Lumbreras, José M. Trigo, Ramón Colomer, Sofía Perea, Carlos Gémez, Ana Ruiz, Rocio García-Carbonero, Hernán Cortés-Funes

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Hospitalization and treatment with broad-spectrum intravenous antibiotics is the standard care for patients with neutropenia and fever. This randomized clinical trial evaluated the feasibility and efficacy of ambulatory care with oral ofloxacin for patients with low risk, chemotherapy-induced neutropenia and fever. METHODS. Patients with solid tumors who were treated with conventional dose chemotherapy, presented with fever (axillary temperature >38°C on 2 occasions or >38.5°C on a single occasion) and neutropenia (absolute neutrophil count,

Original languageEnglish (US)
Pages (from-to)213-219
Number of pages7
JournalCancer
Volume85
Issue number1
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Fingerprint

Ofloxacin
Neutropenia
Fever
Outpatients
Randomized Controlled Trials
Drug Therapy
Ambulatory Care
Patient Care
Hospitalization
Neutrophils
Therapeutics
Anti-Bacterial Agents
Temperature
Neoplasms

Keywords

  • Bacteremia
  • Low risk neutropenia and fever
  • Oral ofloxacin
  • Outpatient therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Outpatient therapy with oral ofloxacin for patients with low risk neutropenia and fever : A prospective, randomized clinical trial. / Hidalgo, Manuel; Hornedo, Javier; Lumbreras, Carlos; Trigo, José M.; Colomer, Ramón; Perea, Sofía; Gémez, Carlos; Ruiz, Ana; García-Carbonero, Rocio; Cortés-Funes, Hernán.

In: Cancer, Vol. 85, No. 1, 01.01.1999, p. 213-219.

Research output: Contribution to journalArticle

Hidalgo, M, Hornedo, J, Lumbreras, C, Trigo, JM, Colomer, R, Perea, S, Gémez, C, Ruiz, A, García-Carbonero, R & Cortés-Funes, H 1999, 'Outpatient therapy with oral ofloxacin for patients with low risk neutropenia and fever: A prospective, randomized clinical trial', Cancer, vol. 85, no. 1, pp. 213-219. https://doi.org/10.1002/(SICI)1097-0142(19990101)85:1<213::AID-CNCR29>3.0.CO;2-D
Hidalgo, Manuel ; Hornedo, Javier ; Lumbreras, Carlos ; Trigo, José M. ; Colomer, Ramón ; Perea, Sofía ; Gémez, Carlos ; Ruiz, Ana ; García-Carbonero, Rocio ; Cortés-Funes, Hernán. / Outpatient therapy with oral ofloxacin for patients with low risk neutropenia and fever : A prospective, randomized clinical trial. In: Cancer. 1999 ; Vol. 85, No. 1. pp. 213-219.
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